Programs by Campus


Cellular and Integrative Physiology


  • PHSL–F 503 Human Physiology (4 cr.) P: Introductory biology (K101, K103), and organic chemistry (C341, C342), and physics (P201, P202), or equivalent. Advanced course in human physiology designed for students with no prior exposure to the discipline. Emphasis on basic physiological mechanisms of control with regard to membrane, neural, endocrine, reproductive, muscle, cardiovascular, respiratory, gastrointestinal, renal, and multisys­tems physiology.
  • PHSL–F 613 Mammalian Physiology Lecture (5 cr.) Neurophysiology, physiology of muscular activity, respiration, circulation, gastro­intestinal physiology, excretion, metabolism, and endocrinol­ogy. Emphasis on basic physiological mechanisms and control systems.
  • PHSL–F 650 Membrane Biophysics (3 cr.) Structure and function of special membranes; mitochondria, RBC, nerve, and muscle.
  • PHSL–F 701 Research in Physiology (arr cr.)
  • PHSL–F 702 Seminar in Physiology (1 cr.) Literature reports and group discussion by students and staff.
  • PHSL–F 705 Molecular and Cellular Physiology (4 cr.) Emphasis is on the principles of cellular structure and function that underlie the physiological functions of many organ systems. Three fun­damental topics will be discussed: cell structure, the organiza­tion of the cells to form tissues, and cell physiology. Modern techniques in cellular physiology will be covered through criti­cal analysis of the primary research literature. Note: Course not currently offered.
  • PHSL–F 710 Physiology of Membranes (2 cr.) P: Consent of instructor. Structure and function of cell membranes. Kinetics and ener­getics of membrane transport. Regulation of intracellular ionic concentrations. Hormonal and pathophysiological modification of membrane function.
  • PHSL–F 711 Integrative Physiology: Cells to Systems (4 cr.) P: No formal prerequisites; background in basic biochemistry and cell biology or cell physiology is recommended. Introductory physiology course for graduate students covering fundamental concepts of cellular and integrative physiology of tissues and organ systems. Basic physiology of the neural, musculoskeletal, cardiovascular, respiratory, renal, endocrine, and gastrointes­tinal systems are covered. At the end of the course, students should have a basic understanding of the physiologic functions of cells, tissues, and organ systems and should understand modern approaches for the measurement and interpretation of physiologic functions. Note: Course not currently offered.
  • PHSL–F 725 Muscle Macromolecules and Contraction (2 cr.) Structure and function of various macromolecules involved in muscle contraction. The aspects covered include excitation-contraction coupling, regulation of myoplasmic free calcium level, the contractile machinery, and force generation. Comparison in skeletal, cardiac, and smooth muscles. Lectures and guided discussion of papers.
  • PHSL–F 780 Special Topics in Physiology (arr cr.) Tutorial instruction in physiology.
  • PHSL–F 782 Physiology and Pathophysiology of Lipid Rafts (1 cr.) P: Graduate cell biology. To acquire a core of essential prin­ciples about lipid raft structure and comprehensive insight into the functional process of these membrane domains by means of introductory lectures, review of current literature, and group discussions with an emphasis on experimental techniques used to examine membrane physiology.
  • PHSL–G 640 Epithelial Cell Biology (1 cr.) P: Graduate cell biology. An integrated approach to epithelial structure/function, and role of subcellular organization in physiology and pathophysiology. Emphasis is on reading original reviews, research papers, and demonstration of techniques to study epithelia function in cul­tured cells, tissues, and model organisms such as zebrafish.
  • PHSL–G 703 Physiology of the Coronary Circulation (1 cr.) P: Graduate physiology. Advanced study of the physiology, pharmacology, and pathophysiology of the coronary circulation using contem­porary methods. Overall goal is to provide a rational basis for functional genomics and modern therapy.
  • PHSL–G 704 Physiological Proteomics (1 cr.) P: Graduate biochemistry. This is a fundamental-based course on theory and practice of contemporary proteomics techniques. Graduate students will learn to select and apply appropriate proteomic technologies in their research through exposure to protein and analytical, quantitative, and informatic approaches to physiologically relevant biomedical problems.
  • PHSL–G 706 Designer Mice: Transgenes and Knockout Animals (1 cr.) P: Graduate cell and molecular biology. An advanced course emphasizing strategies for designing genetically modified mouse models.
  • PHSL–G 707 Physiology of Smooth Muscle (1 cr.) P: Graduate-level physiology course. Advanced study of the physiology of the smooth muscle tissues with focus on the normal physiology and pathophysiology of airway smooth muscle and the airways. Biochemical and physiologic mechanisms in the regulation of contraction, growth, and phenotypic expression in smooth muscle tissues will be explored.
  • PHSL–G 708 Cardiac and Coronary Physiology of Exercise (1 cr.) P: Graduate integrative physiology. Exercise stimulus, quantifi­cation of work, and in vivo responses and adaptations involved in cellular and molecular mechanisms of myocardial and coro­nary artery responses and adaptations to exercise.
  • PHSL–G 712 In Vivo Microcirculatory Physiology (1 cr.) P: Graduate physiology. Fundamental roles of the microcirculation are to provide oxygen and nutrients to the living cells, remove wastes, and maintain hydration of the tissues. These functions are best understood from their cellular and biophysical regulation in the in vivo setting.
  • PHSL–G 713 Angiogenesis (1 cr.) P: Graduate cell biology. Advanced study of angiogenesis. Focus will be on concepts and mecha­nisms of angiogenic processes. Methods of assessment of sprouting angiogenesis will be introduced including demonstra­tions and readings.
  • PHSL–G 714 Development of the Vascular System (1 cr.) P: F710 and Graduate Cell Biology, or consent of instructor. Advanced study of the development of the vascular system. Concepts of vascular development will be explored with an emphasis on the experimental technique used to unravel organ development. This course may be taken for credit only once.
  • PHSL–G 735 Cardiovascular, Renal, and Respiratory Function in Health & Disease (2 cr.) P: G715 and G717. This course will advance fundamental elements of cardiovascular function including basic hemodynamics, cardiac function, respiratory function, ventilator mechanics, gas exchange and kidney func­tion, including control of excretion and regulation of body fluid dynamics. An emphasis will be placed on integrative function of different organ systems.
  • PHSL–G 736 Endocrine and Gastrointestinal Function in Health and Disease (1 cr.) P: G715 and G717. The course emphasizes the use of modern experimental techniques to study mecha­nisms underlying the physiological function of the gastroin­testinal tract and endocrine system. Lectures highlight the molecular and cellular basis for diseases of the gastrointestinal and endocrine systems and how they impact whole animal function.
  • PHSL–G 761 Molecular and Cellular Physiology of Ion Channels (1 cr.) P: Graduate cellular physiology. Advanced ion transport topics selected from current research on channels, pumps, and exchangers. Topics include transporter biophysical characteris­tics, long-term regulation, and electrophysiological and optical methods for study.
  • PHSL–G 762 Renal Physiology (1 cr.) P: Graduate physiology. Reading and discussion of classical papers in renal physiology. Labora­tory experiences will include measurement of renal functions using clearance methods and demonstrations of micropuncture and in vivo techniques.
  • PHSL–G 818 Integrative Cell Biology (3 cr.) This course provides broad understanding of ways in which cells are organized and integrated into tissues. Emphasis is on the function of cells in neural/ neuroendocrine system, cardiopulmonary, renal, and immune systems and in cytomechanics. Modern approaches to the study of tissue function by analysis of cellular regulation will be emphasized.

Academic Bulletins

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