Department of Cellular and Integrative Physiology
Chair: Professor Sturek
Graduate Director: Professor Gallagher
Department E-mail: cellphys@iupui.edu
F499 Independent Research in Medical Physiology and Biophysics (1-4 cr.) Research for undergraduate students. Introduction to research methods and scientific investigation in cellular and medical physiology or biophysics. Research areas include neurobiology, neurophysics, cellular, respiratory, muscle, vascular or renal physiology and endocrinology. Staff
F513 Mammalian Physiology Lecture (5 cr.) Physiology course for medical students covering, neurophysiology, physiology of muscular activity, respiration, circulation, gastrointestinal physiology, excretion, metabolism, and endocrinology. Emphasis on basic physiological mechanisms and control systems but clinical application stressed. Tanner and Staff
X604 Concepts of Health and Disease (4 cr.) A multi-departmental, interdisciplinary course, which integrates concepts of the first year medical curriculum using a problem-based learning approach. Students work in small groups facilitated by faculty to interpret clinical cases and integrate basic science and clinical science concepts. Designed to assess the proficiency at Level I for portions of the competencies. Staff
X/G804 Cellular and Molecular Biology (3 cr.) Cellular and molecular biology for medical students that emphasizes the structural organization, biochemistry and molecular biology of cells. Includes cellular processes, development and differentiation and their relationship to medicine. Wek and Staff
Graduate Courses and Electives
The courses listed below are primarily intended for students seeking the M.S. or Ph.D. degree in cellular and integrative physiology, or the combined M.D. and graduate degrees. Complete and current program information is provided in the departmental Website: www.iupui.edu/~medphys/
F503 Human Physiology (4 cr.) P: introductory biology, organic chemistry, and physics. Graduate-level course in human physiology designed for students with no prior exposure to the discipline. Emphasis on basic physiological mechanisms of control with regard to membrane, neural, endocrine,reproductive, muscle, cardiovascular, respiratory, gastrointestinal, renal, and multisystems physiology. Peavy and Staff
F595 Advanced Physiology (1-15 cr.) P: consent of instructor. Special techniques in advanced areas of physiology.
F701 Research in Physiology (1-15 cr.) Original laboratory research required for fulfillment of M.S. or Doctoral degrees.
F702 Seminar in Physiology (1 cr.) Seminars delivered by invited international, national, and local speakers. Interactive, with questionand-answer period.
F710 Cellular Physiology: From Molecules to Cells (4 cr.) P: undergraduate cell biology; R: biochemistry. Cellular and molecular underpinnings of modern physiology necessary for understanding cell and organ function including cellular and membrane architecture, membrane transport, signal transduction, gene expression, growth and development, cell excitability and contractility. The goal of this course is to provide an understanding of the cellular principles that are common to the function of all organs and tissues. Elmendorf and Staff
F711 Integrative Physiology: From Cells to Tissues (4 cr.) P: no formal prerequisites, although background in basic biochemistry and cell biology or cell physiology is recommended. Introductory physiology course for graduate students covering fundamental concepts of cellular and integrative physiology of tissues and organ systems. Basic physiology of the neural, musculo-skeletal, cardiovascular, respiratory, renal, endocrine, and gastrointestinal systems are covered. At the end of the course, students should have a basic understanding of the physiologic functions of cells, tissues and organ systems and should understand modern approaches for the measurement and interpretation of physiologic functions. Gunst and Staff
F780 Special Topics in Physiology (1-15 cr.) Tutorial instruction in physiology. Staff
GRAD G760 Epithelial Cell Biology (3 cr.) P: F710 and F711 or graduate-level physiology. An integrated approach to epithelial structure and function and the role of subcellular organization in organ physiology and pathophysiology.
GRAD G818 Integrative Cell Biology (3 cr.) P: F710 and F711 or graduate-level physiology. This course provides broad understanding of ways in which cells are organized and integrated into tissues. Emphasis is on the function of cells in neural/neuro-endocrine
system, cardiopulmonary, renal, and immune systems and in cytomechanics. Modern approaches to the study of tissue function by analysis of cellular regulation will be emphasized. Hui and Staff
Focused Elective Courses
Elective courses taken by graduate students in all of the basic sciences who wish to enhance their knowledge of a specific area of physiology (F710 or basic cell biology course recommended; F711 or graduate-level physiology course required). Each course is composed of a 2-3 hour discussion each week for 4-5 weeks. These sessions are informal discussions of review and original research papers covering new technology and progress in each focus area. Demonstration of new laboratory technology relevant to the focus area is an integral part of some focus courses. Students are expected to prepare for each discussion or demonstration session. These courses are offered year-round; times and dates for courses are to be arranged with the instructor. Interested students should contact the graduate program director.
F708 Cardiac & Coronary Physiology of Exercise (1 cr.) P: F710 and F711 or graduate level physiology. Given the current epidemic and foreseeable continuing trend of obesity and diabetes in the U.S., emphasis will be placed on responses and adaptations of the heart and coronary circulation to exercise in the setting of obesity- and diabetes-induced coronary disease. Concepts of exercise stimulus, quantification of work, and in vivo responses and adaptations will be fundamental to studies of cellular and molecular mechanisms of myocardial and coronary artery responses and adaptations to exercise. The approach taken will be the use of current textbooks, select reviews, original research papers, interactive discussion, and laboratory demonstrations and projects. Sturek
F709 In Vivo Microcirculatory Physiology (1 cr.) P: F711 or graduate level physiology. This course will concentrate on in vivo observation of the microcirculation of the small intestine, a skeletal muscle and the cerebral cortex of rats and mice. Techniques to measure blood flow, vascular diameter, tissue oxygen tension and nitric oxide will be explored. An overall goal is to provide students with an overview of the living microcirculation and a beginning understanding of how to evaluate microvascular performance. The approach will use select reviews, original research papers, interactive discussion, and laboratory demonstrations and projects. Typically there are 4 hours of class/laboratory per week over a 4-week session. Bohlen
F712 Designer Mice: Transgenes and Knockout Animals (1 cr.) P: F710 and F711 or graduate level physiology. An advanced course emphasizing the strategies for designing genetically modified mouse models. The approach will involve study of the components of vectors, experimental methods to generate these animals, and approaches to studying these animals. This course will use a combination of readings, discussions and problem sets related to generating, breeding and analyzing transgenic and knockout mice. Gallagher
F713 Angiogenesis (1 cr.) P: F710 or graduate level cell physiology. This course addresses the ability of the body to grow new blood vessels, a process named angiogenesis. Focus will be on concepts and mechanisms of angiogenic processes. The course will start with lectures and workshops covering the basic knowledge of angiogenesis. Methods of assessing angiogenesis in vitro and in vivo will be introduced and also part of laboratory demonstration and independent laboratory experiments. Clauss
F714 Development of the Vascular System (1 cr.) P: F710 or graduate level cell physiology. This advanced level course is offered to graduate students who have an interest in vascular biology. Concepts of vascular development will be explored with an emphasis on the experimental techniques used to unravel organ development. The course will provide an in-depth knowledge of the physiology, cell and molecular biology of the development of the vascular system by means of introductory lectures, assigned reviews of current literature, group discussions and laboratory demonstrations with an emphasis on the experimental techniques used to examine developmental systems. The course will comprise a mixture of didactic lecture, student reading and presentation of original research and review articles, group discussions and laboratory demonstrations. The course will comprise 4 one-hour sessions per week over a 4-week session. Herring
F715 Physiology of the Coronary Circulation (1 cr.) P: F710 and F711 or graduate level physiology. Advanced study of the physiology, pharmacology, and pathophysiology of the coronary circulation using contemporary methods is emphasized. Concepts of hemodynamics, cardiac regulation, vasomotor control, pressure pulses, etc. are reinforced. In vivo studies using angiography, intravascular ultrasound, coronary flow velocity measures, coronary angioplasty, and echocardiography in large animal models are compared with in vitro methods. An overall goal is to provide a rational basis for functional genomics and
modern therapy. Approach will be the use of current textbooks, select reviews, original research papers, interactive discussion, and laboratory demonstrations and projects. Tune
F716 Epithelial Cell Biology (1 cr.) P: F710 or graduate level cell physiology. The course is an integrated approach to studying the structure and functional relationships in epithelial cells, the role of this subcellular organization in normal physiology, and the disturbances that underlie pathophysiology. The emphasis is on reading and discussion of original review articles and research papers, and demonstrations of techniques to study epithelial functions in cultured cells, tissues and model organisms such as the zebrafish. Kempson
F720 Physiological Proteomics (1 cr.) P: F710 or graduate level cell physiology. This is a fundamentals-based course on theory and practice of contemporary proteomics techniques. Graduate students will learn to select and apply appropriate proteomic technologies in their research through exposure to protein analytical, quantitative, and informatic approaches to physiologically-relevant biomedical problems. Witzmann
F726 Physiology of Smooth Muscle (1 cr.) P: F710 and F711 or graduate level physiology. Advanced study of the physiology of the smooth muscle tissues with focus on the normal physiology and pathophysiology of airway smooth muscle and the airways. Biochemical and physiologic mechanisms in the regulation of contraction, growth and phenotypic expression in smooth muscle tissues will be explored. Focus will be on contemporary molecular and cellular and whole animal approaches for the study of muscle physiology, including tissue transfection and the genetic modification of smooth muscle tissues, organ culture, and methods for the measurement of contractility and contractile protein activation in intact and permeabilized tissues including confocal imaging, and in vivo measurement of airway function. Gunst
F761 Molecular and Cellular Physiology of Ion Transport (1 cr.) P: F710 or graduate level cell physiology. Advanced ion transport topics are selected by students from current areas of research on ion channels, pumps, and exchangers. Specific topics include transporter biophysical characteristics, long-term regulation, effects on cell and organ function, electrophysiological and optical methods for study. Format: textbooks, reviews, original research papers, interactive discussion, computer simulations, and laboratory demonstrations and projects. P: graduate cellular physiology or consent of instructor. Sturek and Staff
F762 Renal Physiology (1 cr.) P: F710 and F711 or graduate level physiology. Students will read and discuss several classical or outstanding research papers in renal physiology. Laboratory experiences will include measurement of renal function using clearance methods and demonstrations of micropuncture and in vivo imaging techniques. The course is intended for graduate students who plan to teach or do research in physiology or related disciplines. Tanner
F782 Physiology and Pathophysiology of Lipid Rafts (1 cr.) P: F710 or graduate level cell physiology. The course is targeted to pre-doctoral graduate students in the School of Medicine with interest in advanced study of lipid rafts, a class of membrane domains that compartmentalize signaling molecules and macromolecule complexes to specific cellular sites, and spatially organize signal transduction in cells. The course will reinforce membrane architecture and explore the molecular basis of lipid raft function and dysfunction in disease. The topics to be discussed include: biophysics of lipid lateral organization, biogenesis and maintenance of lipid domains, signal transduction from lipid rafts, and role of lipid rafts in disease. The overall objective is to provide a deep understanding of lipid rafts in membrane organization and cellular function. The course will be comprised of a mixture of didactic lecture, reading and presentation of original research and review articles, group discussion, and laboratory demonstrations. The course will be taught in four 1 hour lectures/week. Elmendorf
F784 Reactive Oxygen Species in Vasculature (1 cr.) P: F710 and F711 or graduate level physiology. Roles of reactive oxygen species in signaling normal vascular tissue functions (contraction and growth) and in disease processes such as the inflammation associated with atherosclerosis and the hyper-constriction associated with hypertension will be addressed. Format: presentation and discussion of review articles and original research papers, laboratory demonstrations and projects. Packer
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