Department of Pharmacology and Toxicology

Chair: Paul Stark Professor Vasko

F604 Pharmacology (120 hrs.) (6 cr.) Lectures, quizzes, laboratory. Required for sophomore medical students. Drugs classified as to site and mechanism of action; representative members of each class of drugs discussed; rational clinical uses emphasized; basic statistical techniques and their application to medical problems are introduced. The laboratory experiments illustrate typical actions of drugs. Student projects may be approved in lieu of part of laboratory. DiMicco

Graduate Courses and Electives

The courses listed below are primarily intended for students seeking the M.S. or Ph.D. degree in pharmacology or toxicology, and for medical students seeking a combined M.D. and graduate degree. Complete program information is provided in the Graduate School Bulletin and/or departmental brochures.

F598 Drugs, Diseases and Poisons (3 cr.) P: a course in basic biology or physiology equivalent to K324 or BIOL 501. Introductory course in pharmacology and toxicology primarily for senior undergraduate students. The course provides an overview of the molecular basis of drug action and pharmacological properties of several of the major drug groups used in medical science. Elharrar

F602 Pharmacology: Lecture (5 cr.) P: Biochemistry B800, Physiology F513, F614. Mode of action of drugs as a basis for therapy. DiMicco, Willis, and Faculty

F801 Introduction to Research in Pharmacology and Toxicology (1-3 cr.) Application of basic laboratory methods to pharmacological problems. Consideration of theoretical principles, instrumentation, and applications. Faculty

F812 Research in Toxicology (cr. arr.) 1 P: F602. Independent laboratory research to fulfill dissertation requirements. Faculty

F813 Clinical Pharmacokinetics (3 cr.) Design and complete mathematical analysis of pharmacokinetic studies in humans. The clinical utility of pharmacokinetics will be stressed, but the course will also have definite value for those involved with drug studies in animals. Hall

F817 Principles of Toxicology (3 cr.) P: F602, Biochemistry B800. This course will teach basic concepts in toxicology such as mechanisms of cell injury, carcinogenesis. Klaunig

F819 Chemical Carcinogenesis (3 cr.) This course examines the mechanisms by which chemicals cause cancer. Emphasis on the uptake, metabolism, cellular targets, and specific stage(s) of the cancer process affected by chemical carcinogens. Klaunig

F825 Research in Pharmacology (cr. arr.) 2 Independent laboratory research for fulfilling the dissertation requirements. Faculty

F826 Seminar in Toxicology (1 cr.) Literature and research reports by students and faculty. Faculty

F830 Seminar in Pharmacology and Toxicology (1 cr.) Literature and research reports by students and staff. Broustovetsky

F836 Pharmacogenetics and Physiological Disposition of Drugs (3 cr.) Factors affecting the absorption distribution, metabolism, and excretion of drugs will be discussed in terms of environmental, biochemical, and physiochemical parameters. Pertinent literature will be reviewed and special problems discussed. Callaghan

F838 Cellular and Molecular Toxicology (3 cr.) This graduate-level course deals with the study of the effects of toxic xenobiotics at the cellular, biochemical, and molecular levels. The course emphasizes the mechanisms through which toxic chemicals interact to evoke toxicological manifestations. Klaunig

F841 Advanced Topics in Toxicology (1-3 cr.) A continuing, nonrepeating series of lectures on advances in toxicology. Topics will examine metabolic, cellular, and molecular mechanisms by which toxic agents produce injury. Klaunig

F843 Pharmacology of Cellular Transduction (3 cr.) This course focuses on mechanisms involved in cellular signal transduction ranging from the molecular biology of receptors to the role of transduction cascades in drug action. Students will participate extensively in discussion of issues. Nicol, Vasko, and Faculty

F850 Experimental Design and Analysis (3 cr.) P: F602. This course presents experimental methods and data analysis used in pharmacological and toxicological experimentation. Emphasis will be on experimental design. Faculty

F899 Senior Elective in Pharmacology (hrs. and cr. arr.) A variety of electives are offered within the department. Specific information on each elective is available in the Senior Elective Program Course Listing, which is updated and published in February of each year. These electives are offered in the Medical Center facilities and in approved programs in clinics and hospitals throughout the state.

F905 Review of Pharmacodynamics (hrs. and cr. arr.) Faculty

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1 Exempt from Incomplete rule (see the University Graduate School Bulletin).
2 This course is more advanced than the senior electives F803 and F806.