Medical Sciences Program (Bloomington)
Assistant Dean and Director: Professor Watkins
General Information
Courses for Medical Students
Courses for Undergraduate Students
Graduate Courses and Electives
The Medical Sciences Program is located on the Indiana University Bloomington campus. The program is designed to provide medical students with an excellent curriculum in the basic sciences, which involves extensive clinical integration at Bloomington Hospital. The hospital provides an auditorium, classrooms, examining rooms, a library, a student lounge, and offices used by the program. Considerable emphasis is placed by the program on close personal contact between medical students and the basic science and clinical faculty, which fosters a rich cooperative environment for learning.
Our medical curriculum is strong because major courses are taught over the entire academic year rather than being confined to a particular semester. This allows students a longer time to master these subjects. For example, during the first semester, freshman medical students enroll in Gross Human Anatomy I, Human Physiology I, Medical Biochemistry I, Human Microscopic Anatomy, Patient/Physician Relationship I, and Microbiology/Immunology. In the second
semester, they enroll in Human Gross Anatomy II, Human Physiology II, Medical Biochemistry II, Neuroscience, and Patient/Physician Relationship II. Sophomore medical students take year-long courses in Pathology, Pharmacology, and Introduction to Medicine, along with semester-long courses in Medical Genetics and Biostatistics. Thus, the sophomore year also provides students with increased time to master these important medical subjects by having them taught throughout the academic year.
The Medical Sciences Program also provides medical students with the opportunity to pursue graduate studies leading to the combined M.D./Ph.D. degree. The program leading to the M.D. degree is administered by the School of Medicine and the Ph.D. degree program is offered by the University Graduate School. A coordinated flexible schedule provides a basis for advanced study and research in a specific field. Close personal faculty guidance is provided in the preclinical curriculum, which is adjustable to the background, needs, and special interests of each student. The student may complete the requirements for an advanced research degree prior to, concurrent with, or upon completion of the clinical years of medicine.
The 1,930-acre Bloomington campus lies in scenic, rolling, heavily wooded terrain in southern Indiana, 50 miles south of Indianapolis. The hilly, wooded acres of the campus are traversed by a small stream, the Jordan River, which creates the illusion of a forest. Most of the university buildings, including Jordan Hall where the Medical Sciences Program is housed, are constructed from native limestone from nearby quarries. The campus is the home of the movie Breaking Away and the famous Little 500 bike race.
Bloomington and its surrounding area offer outstanding cultural and recreational opportunities for students and their families. The university’s world-famous School of Music provides an annual calendar of events that includes opera, chamber groups, ensembles, several orchestras, and student and faculty recitals. The University Theater offers year-round productions. The University Museum of Art exhibits paintings, sculptures, and other art objects, and schedules frequent displays of visiting art collections.
The Indiana University athletic teams are part of the Big Ten Conference and provide a wide variety of spectator sports including soccer, swimming and diving, basketball, track, football, gymnastics, and wrestling. All of the recreational sports facilities of the School of Health, Physical Education, and Recreation are available for student use.
For further information concerning the program, write:
John B. Watkins III, Ph.D., Director
Medical Sciences Program
Jordan Hall 105
Indiana University
Bloomington, IN 47405-4401
(812) 855-8118
E-mail: watkins@indiana.edu
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School of Medicine required courses are restricted to those medical students and graduate students whose departmental graduate programs require the courses. These students must also receive approval from the director of the Medical Sciences Program.
Anatomy
Chemistry
Medicine
Microbiology/Immunology
Pathology
Pharmacology
Physiology
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A550 Gross Human Anatomy I (4 cr.) Study of the gross anatomy of the human, including regional dissections and radiographic and cross-sectional anatomy. Developmental and systemic anatomy, regional anatomy of the thorax, abdomen, pelvis, and perineum. Neff and O’Laughlin
A551 Gross Human Anatomy II (4 cr.) P: A550. A continuation of A550. Developmental and regional anatomy of the extremities, the head, and the neck. Neff and O’Loughlin
A560 Human Microscopic Anatomy (4 cr.) Microscopic study of the anatomy of the human. Tissue histology and embryology of each of the systems of the body. Foley and Mescher
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C580 Medical Biochemistry (3 cr.) A course emphasizing structure-function relationships of cellular components and biosynthesis and degradation of simple and complex cell constituents, as well as regulation of metabolic pathways. Includes biochemical basis for genetic continuity and expression of hereditary characteristics. Daleke and Walczak
C583 Physiological Chemistry (3 cr.) P: C580. Includes the biochemical basis of genetic diseases of carbohydrate, lipid, and protein metabolism; the mechanisms of hormone actions; plasma components, particularly those of the clotting mechanism; the biochemistry of the red blood cell; and the biochemical basis for clinical nutrition. Daleke and Walczak
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M505 Human Genetics and Development (2 cr.) An introduction to the genetics of human traits and inheritable diseases; normal and abnormal development of the human from embryonic life through early childhood. Open only to students in the School of Medicine. Reed
M555 Medical Neurosciences (5 cr.) An interdisciplinary study of the morphological, functional, and clinical aspects of the human nervous system. Ronan, Suthers, and Staff
M605 Introduction to Medicine I (10 cr.) A multidepartmental course designed to introduce clinical medicine. Includes medical history-taking and physical examination skills learned at the bedside with direct patient contact. Clinical medicine is surveyed concurrently with the emphasis on pathophysiology and diagnosis. Problem-solving skills are stressed, including synthesis and interpretation of medical data. Hrisomalos and Staff
M606 Introduction to Medicine II (10 cr.) P: M605. Extension and application of techniques acquired in M605, including workups of patients, medical rounds, and clinicopathological conferences. Hrisomalos and Staff
X600 Patient/Physician Relationship (2 cr.) A multidepartmental interdisciplinary course designed to introduce students to the patient-doctor relationship through interactions with faculty and patients in a variety of settings. In small groups facilitated by primary care and behavioral science faculty, students direct their learning toward the complexity of the context from which a patient seeks medical care. In order to achieve this, students examine normal human behavior and development throughout the life cycle. Issues addressed include preventive health care, sexuality, cultural diversity, minority health issues, religion and spirituality, family dynamics, the economics of health care, and death and dying. Hrisomalos, Watkins, and Staff
X603 Biostatistics (1 cr.) An introductory
course in biostatistics for medical students. Near
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M540 Microbiology/Immunology (5 cr.) Basic concepts of immunology, microorganisms as agents of disease, host-parasite relationships, epidemiology, chemotherapy. Hrisomalos
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C601 General Pathology (5 cr.) Principles of pathology, including a comprehensive introduction to mechanisms of reaction to injury and pathogenesis of disease processes. Braun and Staff
C602 Systemic Pathology (6 cr.) Review of human pathology by organ systems. Braun and Staff
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F605 Principles of Pharmacology I (4 cr.) P: P531- P532 or consent of instructor. Basic principles and clinical aspects of modern pharmacology presented in lectures. Physicochemical properties of drugs. Drugs that affect the autonomic nervous system. Drugs that act on cardiovascular and renal systems. Chemotherapy of cancer, infections, and parasites. Watkins and Staff
F606 Principles of Pharmacology II (4 cr.) P: F605. Drugs that influence the central nervous system. Drugs that influence gastrointestinal and endocrine systems. Immunopharmacology and the pharmacology of allergy and inflammation. Toxicology. Watkins and Staff
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P531 Human Physiology I (3 cr.) Basic principles of general physiology; cardiovascular, digestion, respiration, and renal physiology relevant to humans. Martin and Staff
P532 Human Physiology II (5 cr.) P: P531. Basic physiological principles of temperature regulation, metabolism, endocrinology, and neurophysiology relevant to humans. Martin and Staff
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Anatomy
Medical Sciences
Physiology
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A215 Basic Human Anatomy (5 cr.) (Fall, Spring, Summer II) Intended for science majors and not recommended for first-semester freshmen. This course is team-taught by Medical Sciences faculty. An organ systems approach to the study of the human body, including microscopic and gross structure. The course starts with an introduction to basic cell structure and tissue construction, and continues with the coverage of all human systems with emphasis on the musculoskeletal system, cardiovascular, reproductive, and nervous systems. Bones, models, and prosected cadavers are used to study these topics concurrently in the laboratory. Three lecture periods and two 2-hour laboratory and lecture exams are given outside the regularly scheduled class time. Please see the Schedule of Classes for exam times. There are required textbooks for both lecture and laboratory portions of this course with additional materials provided on the Internet.
A464 Human Tissue Biology (4 cr.) (Spring) This course will provide undergraduates with an in-depth understanding of the biology of human tissues and organs at the cellular and molecular level. Emphasis will be on the normal structural and functional relationships of adult tissues, but will include certain aspects of embryonic tissue formation and medically important tissue abnormalities. After discussing the molecular basis of fundamental types of tissues, we will consider each of the organ systems, including the nervous system, immune system, endocrine system, and
reproductive systems. Developmental aspects of certain specialized tissues such as bone, teeth, and blood cells will be covered in greater detail.
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M131 Disease and the Human Body (3 cr.) (Fall, Spring) Suitable for non-science majors at all levels. Basic science knowledge is advantageous but not necessary. This course is team-taught by Medical Sciences faculty. Provided will be a description of a disease or injury and a discussion of the normal anatomy and physiology of relevant body systems and the alterations that are due to the disease or injury. Included will be various drug and other medical interventions that can be used to diagnose and treat the diseases and injuries. The format consists primarily of lectures with some interactive demonstrations. Four objective exams are scheduled throughout the semester and standard grading policies are utilized. No text is required, and extensive handouts are provided.
M216 Medical Science of Psychoactive Drugs (3 cr.) (Fall, Spring) An entry-level examination of the biological mechanisms underlying the effects of psychoactive drugs. Drug actions in the brain, spinal cord, heart, lungs, liver, and other organs and tissues will be detailed. Molecular mechanisms and genetic factors involved in drug-induced therapeutic and adverse effects will be emphasized. No single appropriate textbook exists. Handouts generated from multiple sources will be provided to cover lecture material.
M450 Undergraduate Research for Biomedical Science (1-6 cr.) P: written permission of faculty member supervising the research and the undergraduate research advisor. Introduction to research methods and scientific investigation in the biomedical sciences. Written report is required upon completion of the research.
M490 Special Topics in Biomedical Science (1-6 cr.) Intensive study of a selected topic in biomedical sciences. Topics will vary.
M499 Internship in Medical Science Instruction (3 cr.) P: Anatomy A215 and/or Physiology P215 and consent of instructor. Supervised teaching experience in undergraduate medical science courses. May be repeated only once for credit.
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P130 Human Biology (4 cr.) Basic concepts in human biology. Covers reproduction and development, physiological regulations, stress biology, and behavioral biology; emphasizes related social problems.
P215 Basic Human Physiology (5 cr.) (Fall, Spring, Summer II) Intended for science majors and not recommended for first-semester freshmen. It is recommended but not required that students complete A215 and C101 prior to enrollment in P215. This course is team-taught by Medical Sciences faculty. An organ systems approach to the study of human body function. Presentation begins with basic cell function and communication systems of the body, progressing to control systems, defense mechanisms, transport, gas exchange, and balancing of nutrients, water, and electrolytes. Focus for the course is on how organ systems contribute to essential metabolic activity and the maintenance of homeostasis. The laboratory emphasizes the application of material presented during lecture and is a required part of the course. Four lecture periods and one two-hour laboratory session per week. Separate objective laboratory and lecture exams are given outside of the regular scheduled class time. Please see the Schedule of Classes for exam times. There are required textbooks for both lecture (same text as A215) and laboratory portions of this course with additional materials provided on the Internet.
P409 Physiology of Exercise (4 cr.) P: an introductory biology course, and general chemistry. Lectures and laboratory on the regulation and integration of metabolic, cardiovascular, and respiratory functions in response to varying intensities of exercise. The influences of these stresses and responses on certain organs and systems, including liver, kidneys, skin, and the gastrointestinal tract.
P416 Comparative Animal Physiology (3 cr.) P: two college biology courses, a college mathematics course, Chemistry C106. Lectures on physiological principles of the respiratory, circulatory, excretory, and related systems in a variety of invertebrate and vertebrate animals.
P417 Neurobiology (3 cr.) P: an introductory biology course and Chemistry C106. Recommended background: a course in cellular physiology or S308 or P416. Physiology of nerves and muscles including sensory receptors, peripheral and central processing of neural information, coordination of motor output, and neurophysiological correlates of behavior.
P418 Laboratory in Comparative Animal Physiology (2 cr.) P or C: P416. Laboratory experiments using a variety of animals to illustrate physiological principles.
P421 Principles of Human Physiology (3-5 cr.) Intended for science majors. Permission of instructor required. This course offers an organ systems approach to the study of biophysical principals governing human body function. Lectures provide a broad survey of the communication and control systems of the
body, defense mechanisms, transport, gas exchange, and balancing of nutrients, water and electrolytes. Problem-solving skills, critical evaluation of data, research and resources in the study of physiology.
P431 Human Physiology (4 cr.) (Fall, Spring) Intended for science majors. This is an introductory course in human physiology designed to introduce the senior undergraduate student and master’s-level graduate student to the function of the human body. This course provides a basic understanding of human organ system function. The emphasis is on demonstrating how organ systems work to maintain homeostasis, a constant yet dynamic internal state that enables us to deal with diverse environmental conditions and activities. Concepts are presented so as to provide students insight into the scientific process, problem solving, and knowledge of resources for the study of human body in health and disease. An opportunity to explore physiological concepts through discussion and experimentation is incorporated into the lecture format of this course. Assignments and exams include seven laboratory reports, seven discussion exercises, four semester exams, and one comprehensive final exam. There is a required textbook; additional materials are provided on the Internet.
P432 Healing Outreach Program Elective (HOPE) (2 cr.) P: consent of instructor. A service-learning course exploring the health and healing benefits of animals. This course partners companion animals, community volunteers, students, and facilities caring for the well-being of people who are physically and/or behaviorally compromised. Reflection and discussion will enhance basic knowledge of physiology and behavior and introduce related research.
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The courses listed below are primarily intended for students seeking the M.S. or Ph.D. degree in the biomedical sciences and for medical students seeking a combined M.D. and graduate degree. Complete program information is provided in the Indiana University Graduate School Bulletin and/or departmental or program brochures.
Anatomy
Pathology
Pharmacology
Physiology
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A464 Histology (5 cr.)
A505 Human Development (1 cr.) P: consent of instructor. Normal and abnormal human development, with a general consideration of human embryology from fertilization through the early neonatal period followed by more detailed analysis of topics in mammalian development biology and teratology.
A512 Introduction to Research in Anatomy (1 cr.) Lectures and demonstrations in current research interests of faculty. Required of all new graduate students.
A513 Introduction to Research Techniques (1 cr.) P: A512. Individual work on a research problem. Staff
A530 Special Topics (2 cr.)
A550 Gross Human Anatomy I (4 cr.)
A551 Gross Human Anatomy II (4 cr.)
A560 Human Microscopic Anatomy (4 cr.)
M555 Medical Neuroscience (5 cr.) An interdisciplinary study of the morphological, functional, and clinical aspects of the human nervous system.
A601-A602-A603 Advanced Gross Anatomy I-II-III (4-4-4 cr.) P: A551, or consent of instructor. I. Structure of the upper and lower
extremities. II. Thorax, abdomen, and pelvis. III. Head, neck, and gross brain. All include detailed dissection and lectures and discussion on current literature to determine relation of structure to function.
A610 Comparative Neuroanatomy (2 cr.) P: consent of instructor, graduate standing, and one neuroscience course or equivalent. A comparison of the central nervous system of mammalian and nonmammalian vertebrates, including a laboratory study of representative specimen.
A664 Selected Topics in Advanced Microscopic Anatomy (2 cr.) P: A560 or consent of instructor. Advanced instruction in the microscopic structure of selected animal cell systems, involving discussion and review of current literature and research with these systems. Topic will change with each offering.
A800 Research in Anatomy (cr. arr.)
A850 Seminar in Anatomy and Physiology Medicine (cr. arr.)
G901 Advanced Research (6 cr.) Authorized by director.
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C601 General Pathology (5 cr.)
C602 Systemic Pathology (6 cr.)
C800 Advanced Pathology (cr. arr.) P: C603. Subject material and hours arranged to conform to needs of students.
C858 Experimental Pathology (5 cr.) Review and performance of selected experiments in pathology illustrating the types of pathologic processes.
C859 Research in Pathology (cr. arr.) Supervised initiation of a research project in pathology. Counseling in the completion of a thesis.
C862 Basic Pathologic Techniques (5 cr.) Methods of the histologic and chemical laboratories of pathology; principles of examination used in the usual procedures of surgical and autopsy pathology.
C875 Biochemical Pathology (3 cr.) P: C603 or B800. A survey of biochemical pathology as demonstrated by recent advances in research in pathology. Selected topics for lecture and discussion will include aspects of tissue, cellular, subcellular, and molecular pathology.
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F605 Principles of Pharmacology I (4 cr.)
F606 Principles of Pharmacology II (4 cr.)
F611 Methods of Pharmacology I (3 cr.) P: consent of instructor. Chemical and biological procedures used in pharmacological research. Lectures and demonstrations of techniques used for the determination of specific substances in biological material.
F612 Methods of Pharmacology II (3 cr.) P: F611. Laboratory application of principles and techniques presented in F611 to practical problems in pharmacological research. Introduction to data handling.
F513 Graduate Pharmacology I (3 cr.) P: F605-F606 or consent of instructor. Molecular mechanisms of drug action, drug-receptor interactions, drug metabolism, and pharmacokinetics.
F614 Graduate Pharmacology II (3 cr.) P: F513 or consent of instructor. Continuation of F513. Molecular mechanisms of drug action, drug-receptor interactions, drug metabolism and pharmacokinetics.
F615 Chemotherapeutic Pharmacology (3 cr.) P: F605-F606 or consent of instructor. Basic principals of use of drugs as selectively toxic agents and of chemotherapy of bacterial, parasitic or viral diseases and malignancies.
F616 Molecular Pharmacology (3 cr.) P: F605-F606 or consent of instructor. Molecular mechanisms as they relate to drug action. Biological transducers, receptor mechanisms, subcellular phenomena in the actions of drugs on mammalian systems.
F617 Pharmacology of Drug Metabolism (3 cr.) P: F605-F606 or consent of instructor. Physicochemical principles involved in the absorption, distribution, metabolism, and excretion of drugs and other foreign compounds in the mammalian organism.
F618 Pharmacokinetics (3 cr.) P: F617. Kinetic aspects of absorption, distribution, and excretion of drugs in the mammalian organism. Compartmentalization, multiphasic decay curves, and computerized treatments.
F619 Endocrine Pharmacology (3 cr.) P: F605-F606 or consent of instructor. The pharmacology of hormones. Biosynthesis, structures, actions, and degradation of hormones endogenous to mammalian species. Structure and pharmacological activity of synthetic analogs and antagonists of naturally occurring hormones.
F620 Special Topics in Pharmacology (3 cr.) P: F605-F606 or consent of instructor. Special topics of current interest in pharmacology. May be repeated.
F621 Readings in Pharmacology (1-3 cr.) Supplementary readings and tutorial discussions in aspects of pharmacology to fit the needs of individual students or for specialized areas.
F625 Research in Pharmacology (cr. arr.) Original research as approved by the department.
F630 Seminar in Pharmacology (1 cr.) Research reports by students, faculty, and invited guests.
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L500 Independent Study (cr. arr.) P: written permission of faculty member supervising research.
P409 Physiology of Exercise (4 cr.)
P416 Comparative Animal Physiology (3 cr.)
P417 Neurobiology (3 cr.)
P418 Laboratory in Comparative Animal Physiology (2 cr.)
P421 Principles of Human Physiology (3-5 cr.) Intended for science majors. Permission of instructor required. This course offers an organ systems approach to the study of biophysical principles governing human body function. Lectures provide a broad survey of the communication and control systems of the body, defense mechanisms, transport, gas exchange, and balancing of nutrients, water, and electrolytes. Problem-solving skills, critical evaluation of data, research and resources in the study of physiology.
P509 Physiological Adaptations (3 cr.) Mechanisms of adaptation and acclimatization of invertebrate and vertebrate animals to environmental conditions. Seminar-type course.
P510 Control Systems Theory in Biology (4 cr.) P: introduction to calculus; P531 or
equivalent. Predicting the properties of physiological systems from the dynamic properties of their component parts. Laboratory emphasizes analog and digital simulation techniques.
P512 Introduction to Research in Physiology (1 cr.) Introduction to areas and methods of current faculty research. Required for all new graduate students.
P513 Introduction to Research Techniques (1 cr.) P: P512. Individual work on a research problem.
P530 Special Topics (cr. arr.) P: consent of instructor. Work in advanced areas in physiology.
P531 Human Physiology I (3 cr.)
P532 Human Physiology II (5 cr.)
P541 Advanced Physiology I: Neurophysiology (3-5 cr.) P: P531 or consent of instructor. From molecular to behavioral level, with special emphasis on electrophysiology and reflexes.
P543 Neurophysiology Seminar (2 cr.) P: P541. May be taken more than once with consent of the department, for a maximum of 6 credit hours.
P547 Topical Seminar in Physiology (2 cr.) P: graduate standing and consent of instructor. Discussion and review of current research and literature in physiology. Topic and instructor will change from semester to semester.
P548 Neuroethology (2 cr.) P: consent of instructor. The function of nerve cells in controlling the natural behavior of animals. Sensory, integrative, and motor processes underlying selected behavior patterns of invertebrate and vertebrate animals.
P550 Seminar in Physiology (1-5 cr.) Discussion and review of current research and literature in selected topics, including neural, temperature regulation, cardiovascular, renal, and respiratory physiology.
P551 Advanced Physiology II: Circulation, Respiration (3 cr.) P: P531 or equivalent. Lecture and seminar discussions of current literature with emphasis on physical models.
P561 Advanced Comparative Animal Physiology (3 cr.) P: P531, P416 or equivalent, or consent of instructor. Lectures and discussions of current literature on mechanisims and adaptations of respiration, temperature regulation, locomotion, and osmoregulation from a comparative approach. Topics will be covered in succeeding years on a rotating basis. May be taken more than once for different topics.
P575 Advanced Physiology Exercise (3 cr.) P: P532 or consent of instructor. Study of the regulation and integration of metabolic, cardiovascular, respiratory, endocrinological, and biochemical functions of the human body in response to exercise of all types and durations.
P576 Advanced Physiology: Work and Environmental (3 cr.) P: P575 or consent of instructor. Mechanisms of contraction and neuromuscular control. Metabolic energy, cost efficiency, and the fuels of work. The adjustments and regulation of chemical and thermal homeostasis. Effects of environmental factors, training, age, health, and disease on metabolic, cardiovascular, and respiratory adjustments to exercise.
P620 Renal Physiology (3 cr.) P: P531, A464, P551, C580. Designed for graduate students in physiology. Covers recent advances in acid-base balance, blood pressure regulations, and salt balance in relation to endocrinology.
P800 Research in Physiology (cr. arr.)
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