Chair: Paul Stark Professor Vasko

F200 Pharmacology for Respiratory Therapy Students (2 cr.) P: sophomore respiratory therapy program. The biochemical and physiological action of major drug classes; emphasis is placed on the mechanism of action and side effects of drugs, using clinically relevant examples. Applications to respiratory problems are discussed. Elharrar

F604 Pharmacology (120 hrs.) (6 cr.) Lectures, quizzes, laboratory. Required for sophomore medical students. Drugs classified as to site and mechanism of action; representative members of each class of drugs discussed; rational clinical uses emphasized; basic statistical techniques and their application to medical problems are introduced. The laboratory experiments illustrate typical actions of drugs. Student projects may be approved in lieu of part of laboratory. DiMicco and Willis

Graduate Courses and Electives

The courses listed below are primarily intended for students seeking the M.S. or Ph.D. degree in pharmacology or toxicology, and for medical students seeking a combined M.D. and graduate degree. Complete program information is provided in the Graduate School Bulletin and/or departmental brochures.

F602 Pharmacology: Lecture (5 cr.) P: Biochemistry B800, Physiology F613, F614. Mode of action of drugs as a basis for therapy. DiMicco, Willis, and Staff

F603 Pharmacology: Laboratory (2 cr.) Taught in conjunction with F602. DiMicco and Staff

F801 Introduction to Research in Pharmacology and Toxicology (1-3 cr.) Application of basic laboratory methods to pharmacological problems. Consideration of theoretical principles, instrumentation, and applications. Staff

F803 Renal Pharmacology (3 cr.) Physiological and metabolic responses of the kidneys to various classifications of drugs. Willis

F804 Introduction to Pharmacology and Toxicology I (3 cr.) This course examines the fundamental principles of pharmacology and toxicology for the beginning graduate student, as an introduction to the discipline. Richter and Staff

F806 Cellular Pharmacodynamics (3 cr.) P: Biochemistry B810, Physiology F765. The effects of drugs and hormones on intracellular systems and cellular metabolism will be examined to define mechanisms of drug action. Staff

F808 Myocardial Biology (3 cr.) The cellular biology of muscle, with emphasis on the regulation of the internal ionic milieu and its effect on function of cardiac cells. The contractile proteins and the ion transport systems, Na+, K+-ATPase, sarcoplasmic reticulum and mitochondria will be considered in detail. Besch

F809 Neuropharmacology (3 cr.) P: F602 and Biochemistry B835, or permission of instructor. Drugs that affect the nervous system, with particular emphasis on their central action. Although neurochemical effects will be stressed, evidence from neurophysiology and behavior will also be considered. Richter

F810 Pharmacology of Autonomic Cardiovascular Control: Central and Peripheral Mechanisms (3 cr.) The physiology and pharmacology of sympathetic and parasympathetic nervous control of the cardiovascular system; pharmacology of synaptic mechanisms in peripheral and central pathways controlling autonomic outflow. DiMicco

F811 Concepts in Pharmacology (2 cr.) The course will survey classic and recent literature that establishes current ideas and approaches to research topics in pharmacology. Basic concepts of various disciplines will be applied to pharmacology research. Staff

F812 Research in Toxicology (cr. arr.)¹ P: F602. Independent laboratory research to fulfill dissertation requirements. Staff

F813 Clinical Pharmacokinetics (3 cr.) Design and complete mathematical analysis of pharmacokinetic studies in humans. The clinical utility of pharmacokinetics will be stressed, but the course will also have definite value for those involved with drug studies in animals. Hall

F814 Introduction to Pharmacology and Toxicology II (3 cr.) P: F804. This course will expand on fundamental principles of pharmacology and toxicology, surveying recent advances in the field. Elharrar and Staff

F816 Clinical Toxicology (3-5 cr.) Signs and symptoms resulting from common poisons and drugs; chemical analyses as aids in diagnosis. Staff

F817 Principles of Toxicology (2-5 cr.) P: F602, Biochemistry B800. This course will teach basic concepts in toxicology such as mechanisms of cell injury, carcinogenesis. Klaunig

F819 Chemical Carcinogenesis (3 cr.) This course examines the mechanisms by which chemicals cause cancer. Emphasis on the uptake, metabolism, cellular targets, and specific stage(s) of the cancer process affected by chemical carcinogens. Klaunig

F820 Cancer Chemoprevention (3 cr.) This course will examine the biochemical and molecular mechanism of action of natural and synthetic cancer chemopreventive agents. Klaunig

F825 Research in Pharmacology (cr. arr.)² Independent laboratory research for fulfilling the dissertation requirements. Staff

F826 Seminar in Toxicology (1 cr.) Literature and research reports by students and staff. Staff

F830 Seminar in Pharmacology and Toxicology (1 cr.) Literature and research reports by students and staff. Klaunig and Safa

F832 Drug-Protein Interactions (3 cr.) Drug-protein interactions such as drugs modifying enzyme action; drugs acting at cell membrane receptors; drug binding to extracellular proteins. Emphasis is placed on measuring drug-protein interaction. Queener

F835 Molecular Mechanism of Drug Action (3 cr.) Biochemical mechanisms underlying drug actions and reactions including toxicologic effects of drugs will be covered, with emphasis on molecular mechanisms involving drug receptor interaction, the actions of drugs and hormones on regulatory mechanisms in various disease states. Staff

F836 Pharmacogenetics and Physiological Disposition of Drugs (3 cr.) Factors affecting the absorption distribution, metabolism, and excretion of drugs will be discussed in terms of environmental, biochemical, and physiochemical parameters. Pertinent literature will be reviewed and special problems discussed. Callaghan

F838 Cellular and Molecular Toxicology (3 cr.) This graduate-level course deals with the study of the effects of toxic xenobiotics at the cellular, biochemical, and molecular levels. The course emphasizes the mechanisms through which toxic chemicals interact to evoke toxicological manifestations. Klaunig

F840 Advanced Pharmacology and Toxicology (2-5 cr.) P: F602. Advanced studies of pharmacodynamic mechanisms in nervous system and other topics in pharmacology and toxicology. Experimental design related to recent advances and current hypotheses concerning drug action and toxicity. Zhang and Staff

F841 Advanced Topics in Toxicology (2 cr.) A continuing, nonrepeating series of lectures on advances in toxicology. Topics will examine metabolic, cellular, and molecular mechanisms by which toxic agents produce injury. Klaunig

F842 Tumor Metabolism and Chemotherapy (3 cr.) P: F602, Biochemistry B800. Biochemical alterations in neoplasia and mechanisms of chemical, hormonal, and viral carcinogenesis. Weber

F843 Pharmacology of Cellular Transduction (3 cr.) This course focuses on mechanisms involved in cellular signal transduction ranging from the molecular biology of receptors to the role of transduction cascades in drug action. Students will participate extensively in discussion of issues. Nicol, Vasko, and Staff

F850 Experimental Design and Analysis (3 cr.) P: F602. This course presents experimental methods and data analysis used in pharmacological and toxicological experimentation. Emphasis will be on experimental design. Staff

F899 Senior Elective in Pharmacology (hrs. and cr. arr.) A variety of electives are offered within the department. Specific information on each elective is available in the Senior Elective Program Course Listing, which is updated and published in February of each year. These electives are offered in the Medical Center facilities and in approved programs in clinics and hospitals throughout the state.

F905 Review of Pharmacodynamics (hrs. and cr. arr.) Staff

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