In addition to offering a variety of courses and degree programs, the department is continuously involved in a number of innovative research, instructional, and service projects that include the following:

• Center for Health and Safety Studies provides support services to the university community, to the profession, and to the state of Indiana through conferences, research projects, and the management of grants and contracts.
• Center for Minority Health has the mission of research, outreach, programming, and training with regard to public health and health disparities. 
• Center for Sexual Health Promotion is a collaborative effort of sexual health scholars from across the IU campuses and strategic partner academic institutions around the globe. These scholars, in partnership with practitioners from community-based health organizations, government, and industry, work toward advancing the field of sexual health through research, education, and training. 
• Center for Student Leadership Development The center works with existing student leaders who volunteer their time to influence and be involved with their student organizations as well as develop and deliver both academic courses and special extracurricular experiences that expand students' leadership skills and capacities.
• Indiana University Institute for Drug Abuse Prevention is directed by faculty in the Department of Applied Health Science and provides a research and service infrastructure for a wide range of drug prevention grants and contracts.
• Prevention Insights is a statewide clearinghouse of prevention technical assistance and information about alcohol, tobacco, and other drugs, funded in part by a contract with the Indiana Family and Social Services Administration, Division of Mental Health and Addiction. The mission of the center is strengthening a behavioral health system that promotes prevention, treatment, and recovery. 
• Rural Center for AIDS/STD Prevention has, as its major focus, the promotion of AIDS/STD prevention in rural America.
• Tobacco Control and Wellness Research Working Group provides advanced training to graduate students interested in tobacco control and wellness research. Its goals include cultivating tobacco control and wellness research partnerships between faculty and graduate students.