School of Medicine Indianapolis

Chairperson
John Eble

Departmental E-mail
slwheele@iupui.edu

Departmental URL
www.pathology.iupui.edu

Graduate Faculty
Degrees Offered
Special Departmental Requirements
Master of Science in Pathology Degree
Doctor of Philosophy Degree in Experimental Pathology
Courses

Graduate Faculty

Culbertson Professor of Pathology
John Pless

Distinguished Professor
Bernardino Ghetti (Medical and Molecular Genetics, Neurobiology, Psychiatry)

Nordschow Professor of Laboratory Medicine
James Smith (Emeritus)

Professors
Stephen Allen, Biagio Azzarelli, Nils Bang, Michael Clark* (Pediatrics), John Critser, Thomas E. Davis Jr., John Eble, Kenneth Fife (Microbiology and Immunology, Medicine), Roy Geib, Melvin Glick*, Richard Gregory (Oral Microbiology), Dean Hawley, M. E. Hodes (Medical and Molecular Genetics, Medicine), Meredith Hull*, Richard Kohler* (Medicine), Chao-Hung Lee, Diane Leland, Richard Neiman (Emeritus), Lawrence Roth (Emeritus), Kenneth Ryder, Aristotle Siakotos, Thomas Ulbright*, Lawrence Wheat* (Medicine), Moo Nahm Yum

Associate Professors
John Baenziger*, Harvey Cramer, Constance Danielson*, Randall Duncan (Medicine), Patricia Kotylo, Vimalkumar Patel*, C. Pedro Picardo*

Assistant Professors
Liang Cheng*, Jill Murrell, Carrie Phillips*, Ruben G. Vidal*, Cheryl Younger*

Graduate Advisor
Professor Diane Leland, Riley Hospital 0969, (317) 274-0148

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Degrees Offered

Master of Science in Pathology and Doctor of Philosophy

Areas of Specialization
Specialization is available in various areas of anatomical, clinical, and experimental pathology. Areas of emphasis are neuropathology, experimental pathology, clinical chemistry, clinical microbiology, hematopathology, immunohematology, molecular pathology, and others. All M.S. and Ph.D. degree students choose one of these subspecialties for concentrated course work and thesis/dissertation research.

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Special Departmental Requirements

(See also general University Graduate School requirements.)

Admission Requirements
Applicants for the M.S. degree must have a bachelor's degree in medical technology, biochemistry, microbiology, or other biological science. Applicants for the Ph.D. degree must be medical students, have a doctoral degree in medicine, dentistry, or veterinary medicine, or have earned an M.S. or M.A. degree (with research thesis) in experimental pathology or related basic science. A completed application form, transcripts from all colleges attended, letters of recommendation, and scores on the Graduate Record Examination General Test (and, ideally, one Subject Test) must all be received before an application will be considered. A minimum grade point average of 3.0 (B) in undergraduate science courses and an interview with the graduate program committee are required.

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Master of Science in Pathology Degree

Course Requirements
Requirements vary, according to the area of emphasis.

M.S. Degree in Pathology with Emphasis in an Area of Experimental Pathology
This course of study is recommended for students who plan to continue on to the Ph.D. after completing the M.S. degree. A minimum of 30 credit hours, including completion of a graduate-level general biochemistry course with a grade of C or higher and C808 Graduate Seminar; a maximum of 2 credits of C808 can be applied toward the required 21 credit hours of course work. Most students will also take C603 General Pathology. A grade of B or higher is required in C603 if the student plans to continue on to the Ph.D. At least 21 credit hours must be in courses other than research. At least 3 but not more than 9 credits must be in research.

M.S. Degree in Pathology with Special Concentration in Pathology Laboratory Sciences
This course of study is recommended for students who do not plan to continue on to the Ph.D. after completing the M.S. degree. The M.S. with special concentration in one of the subspecialty areas of clinical pathology requires at least 30 credit hours but may require up to 40 credit hours or more, depending on the area of concentration, the background of the student, and the prerequisites needed for certain advanced courses. At least 3 but not more than 9 credit hours in research, a graduate-level biochemistry course, and C808 Graduate Seminar are required; a maximum of 2 credits of C808 can be applied toward the required 21 credit hours of course work. Development of each student's curriculum of lecture and laboratory courses and of research and teaching requirements will be a joint effort of the student and the graduate advisory committee. Course work differs, depending on whether the M.S. degree is to be focused in the areas of clinical chemistry, clinical microbiology, hematopathology, immunohematology, or other clinical laboratory specialty area.

Thesis
Required. In special cases, published research may be substituted for the thesis. Consult the graduate advisor.

Final Examination
Oral, on the thesis.

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Doctor of Philosophy Degree in Experimental Pathology

Only those students who are medical students, have a doctoral degree in medicine, dentistry, or veterinary medicine, or have already earned the M.S. or M.A. degree (research thesis) in experimental pathology or related basic science are eligible to apply for the Ph.D.; all others will be enrolled in a program leading to the M.S. degree.

Course Requirements
A total of 90 credit hours, of which a minimum of 40 credit hours must be in courses other than research. Required courses include a graduate-level general biochemistry course, one additional graduate biochemistry or molecular biology course, C603 Pathology or equivalent, and C808; a maximum of 4 credits of C808 can be applied toward the required 40 credit hours of course work. Additional appropriate courses will be identified by the student's advisory committee and may be selected from core courses in the Department of Pathology and Laboratory Medicine or other graduate basic medical science departments. A minimum of 45 credit hours in dissertation research (C859) is required.

Grades
Overall average of at least a B (3.0). A grade of C or higher in a graduate-level general biochemistry course and a grade of B or higher in C603 Pathology are required.

Minor
At least 12 credit hours in a related discipline or in life science involving lecture/laboratory courses other than research. If a life sciences minor is approved, a minimum of 6 credit hours must be obtained in a single department.

Foreign Language
Not required.

Qualifying Examination
Written and oral, covering course work and research proposal.

Research Proposal
Required (in form of a National Institutes of Health grant proposal); must be approved by student's advisory committee before completion of dissertation research.

Dissertation
Required.

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Courses

C603 General Pathology (6 cr.) Basic concepts and principles of disease processes.

C700 Clinical Chemistry I (3 cr.) P: B500 or B800 or equivalent. Methodology, instrumentation, and interpretation with clinical correlation of procedures in the clinical chemistry laboratory.

C701 Clinical Chemistry II (2-3 cr.) P: B500 or B800 or equivalent. Special clinical chemistry therapeutic drug monitoring and radioassay, radioimmunoassay, and enzyme immunoassay.

C800 Advanced Pathology (cr. arr.) Subject material and credit hours arranged to conform to needs of student.

C802 Advanced Morphologic Hematology (2 cr.) P: consent of instructor. A graduate-level course with emphasis on diagnostic morphologic hematology. This course covers several aspects of morphologic hematology, including erythrokinetics, myeloid and erythroid morphology, leukemia classification, myelodysplastic syndromes, myeloproliferative disorders, and newer concepts in diagnostic hematology.

C803 Diagnostic Immunopathology (2 cr.) P: basic undergraduate immunology and permission of instructor. Emphasis on immunobiology and diagnostic immunopathology. This course covers several aspects of immunopathology including autoimmune disease, transplantation biology, immunodeficiency disorders, and use of molecular diagnostics.

C808 Graduate Seminar in Pathology (1 cr.) P: consent of instructor. One-hour, graduate-level seminar series with emphasis on experimental pathology. First-year graduate students present critical literature reviews of contemporary research topics. More advanced students present proposals and reports of their research.

C820 Advances in Diagnostic Microbiology (3 cr.) Discussions of infectious diseases and agents of infectious diseases including source, clinical manifestations, pathogenesis, epidemiology, treatment, and prevention and control, and the correlation of these subjects with laboratory diagnostic methods. Contemporary subjects will be emphasized.

C850 Cellular Structure of the Nervous System (3 cr.) Cellular structure and ultrastructure of the C.N.S. in normal and experimental situations, including cell biology of neurons, astrocytes, oligodendroglia, brain macrophages, mast cells, brain vessels, and barriers. Organization of neural systems into global and point-to-point circuits; generative and regressive phenomena; and cerebral transplantation in neurodegenerative conditions.

C858 Experimental Pathology (5 cr.) Review and performance of selected experiments in pathology illustrating the types of pathologic processes.

C859 Research in Pathology (cr. arr.)* Supervised initiation of a research project in pathology, and counseling in the completion of a thesis.

C862 Basic Pathologic Techniques (5 cr.) Methods of the histologic and chemical laboratories of pathology; principles of examination used in the usual procedures of surgical and autopsy pathology.

C875 Biochemical Pathology (3 cr.) P: C603 or B800. A survey of biochemical pathology as demonstrated by recent advances in research in pathology. Selected topics for lecture and discussion will include aspects of tissue, cellular, subcellular, and molecular pathology.

G556 Methods of Humane Animal Experimentation (1 cr.) The purpose of this course is to provide graduate students entering careers in life science disciplines with the opportunity to obtain training in the proper care and humane use of laboratory animals. Federal regulations and considerations in the selection of animal models will also be discussed.

G655 Research Communications Seminar (2 cr.) Study of the methodological and systematic treatments of scientific data required for effective communication through written primary and secondary research publications, oral presentations, abstracts, post-presentations, and grant proposals.

G890 Methods in Molecular Biology and Pathology (3 cr.) P: G865 or J838, and consent of instructor. Basic principles and techniques in molecular biology and pathology. Particular emphasis will be on molecular techniques that can be used to study problems related to biochemistry and pathology.

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