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University Graduate School  
Kirkwood Hall 111 
Indiana University 
Bloomington, IN 47405 
(812) 855-8853 
Contact Graduate Office 

Microbiology and Immunology

Graduate Faculty
Associate Faculty
Special Departmental Requirements
Master of Science Degree
Doctor of Philosophy Degree

School of Medicine

Professor Hal E. Broxmeyer

Departmental URL:

Graduate Faculty

Richard Bockrath, Janice Blum, Hal E. Broxmeyer, David Donner, Richard Haak, Ann Roman, Raoul Rosenthal, Robert Schloemer, Arun Srivastava

Associate Professors
Michael Klemsz, Steven Larsen, Warner Wegener, Charles Wilde III

Assistant Professors
Ghalib Alkhatib,* Randy Brutkiewicz,* Alexander Dent,* Johnny He,* Mark Kaplan*

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Associate Faculty

Byron Batteiger (Medicine), Zacharie Brahmi (Medicine), Kenneth Fife (Medicine), Robert Jones (Medicine), Chris Miller (Dentistry), Stanley Spinola (Medicine)

Associate Professors
Darron Brown (Medicine), D. Wade Clapp (Pediatrics), Kenneth Cornetta* (Medicine), Edward Srour (Medicine), David Wilkes (Medicine)

Assistant Professor
Thomas Gardner* (Urology)

Graduate Advisor
Associate Professor Michael Klemsz, Medical Science Building 257, (317) 274-7671; fax: (317) 274-4090; e-mail: mklemsz@iupui.edu

Degrees Offered
Master of Science and Doctor of Philosophy

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Special Departmental Requirements

(See also general University Graduate School requirements.)

Admission Requirements
The Graduate Record Examination General Test is required, and the Subject Test in cellular and molecular biology is recommended. Undergraduate courses in basic biology, including cell biology and genetics; general and organic chemistry; physics; mathematics, including calculus; and biochemistry. Deficiencies should be removed during the first year of enrollment. Overall grade point average of at least 3.0 (B).

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Master of Science Degree

Course Requirements
At least 30 credit hours, including thesis, B500 Biochemistry , and J601 Microbiology or J822 or their equivalents. At least 20 of the required 30 credit hours must be in courses other than research; a maximum of 4 credits in J800 can be applied toward these 20 credit hours.

Overall average of at least a B (3.0).

Comprehensive Examination
Required at completion of second semester of study.

Required (a minimum of 8 credit hours of J810).

Final Examination
Oral defense of thesis.

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Doctor of Philosophy Degree

Focus Areas
The major focus areas are immunology, pathogenesis, and cancer. Students entering the program may design a course of study from one of these areas through a combination of selected course work and research activities.

Course Requirements
A total of 90 credit hours, of which a minimum of 26 credit hours must be in courses other than research. Required courses include G817 and G865, or their equivalent, one credit of G504 and three semesters of J830 Seminar in Microbiology. Students take 2 credits of J802 Introduction to Research in Microbiology and Immunology. A minimum of four courses is selected from an area of emphasis: immunology, pathogenesis, or cancer. A maximum of 4 credits of J800 can be applied toward the required 26 credit hours of course work. G817 and G865 can be applied toward the minor requirements with approval of the minor representative. A minimum of 40 credit hours of dissertation research (J810) is required.

Overall average of at least a B (3.0).

A minimum of 12 credit hours in a related field or in life science. These credits must be in lecture or laboratory courses other than research and must meet the requirements of the department in which the minor is taken. For the life sciences minor, a minimum of 6 credit hours must be obtained in one department.

Ph.D. Minor in Cellular and Molecular Biology of Biomedical Systems
A minimum of 12 credit hours of course work outside the studentís major department, including G865 Fundamental Molecular Biology and either G817 Eukaryotic Cell Biology or F705 Molecular and Cellular Physiology (unless these are required by the major department). Since the minor is intended to expose the student to both cellular and molecular biology, at least one course (and preferably two) from each area should be taken. Courses for the minor must be selected from the following list and approved by the advisory committee, the minor representative of which will be selected from outside the studentís major department. Courses: Anatomy D863, D866; Biochemistry B807, B810, G817, B841; Medical and Molecular Genetics Q612, Q620, Q622; Microbiology and Immunology J805, J821, J826, J828, J837, J838; Pharmacology and Toxicology F808, F832, F834, F835, F842, F843; Physiology and Biophysics F705, F710, F724, F765; Graduate G595, G865, G890.

Ph.D. Minor in Cancer Biology
A minimum of 12 credit hours outside of the studentís major department, including two courses from the following list of four: Q622 Cytogenetics of Malignancies, F819 Chemical Carcinogenesis, J842 Neoplastic Determinants, BIOL516 Molecular Biology of Cancer. At least one credit of G504 Introduction to Research Ethics must also be taken. The remainder of the minor will be selected from the following courses: Graduate G865, G817, G807; Biochemistry and Molecular Biology B807, B810; Medical and Molecular Genetics Q620, Q622; Microbiology and Immunology J805, J807, J828, J829, J837, J840, J842, J854; Pharmacology and Toxicology F819, F820. The minor program must be approved by the studentís Advisory Committee which will take into consideration the studentís total didactic experience. In the case of combined M.D./Ph.D. students, the Committee may approve substitution of appropriate medical school courses. The minor representative on this Committee will be selected from outside the studentís major department and must be a member of the Cancer Biology Training Program.

Qualifying Examination
Within the first 25 months of studies, the student submits a written research proposal in the form of a grant application to the advisory committee. At this time, the student has both a written examination based on course work and an oral examination based primarily on the written research proposal. The student can request an extension of four months from the faculty to take the qualifying examination. Doctoral studies are continued if the qualifying examination and other work, including research, are deemed satisfactory by the majority of the advisory and research committees.

Final Examination
Oral defense of the dissertation.

Other Provision
Submission of a manuscript based on the dissertation research for publication in a primary journal in the field required. Students will develop teaching skills as instructors in J201 during the first two years of graduate training and additional teaching experiences can be arranged.

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J510 Infectious Microbes and Host Interactions (3 cr.) P: graduate-level biochemistry. Emphasis on the molecular and cellular events which permit pathogenic bacteria and viruses to enter human cells and disrupt cell function while evading the hostís immune system.
J601 Medical Immunology (2 cr.) Introduction to natural and acquired immune mechanisms, with consideration of their significance to medicine. Topics will include both normal and abnormal immune processes, including recovery from and prevention of disease, immune-mediated pathological processes, tumor immunology, immunodeficiency and auto-immunity. Designed to precede and complement J602 Medical Microbiology.
J611 Introduction to Biophysics I (3 cr.) P: consent of instructor. An introductory course including principles of mechanics, fluid statics and dynamics, introductory classical thermodynamics and diffusion, electricity, feedback and control as related to biologically significant systems.
J612 Introduction to Biophysics II (3 cr.) P: J611 or equivalent. The statistical basis of physical principles governing molecular processes, including diffusion and transport across membranes; thermodynamics; probability and the relationship of information theory, statistical mechanics, quantum mechanics, Boltzmann and Poisson distributions; and flow of movements and mass. Applications to current biophysical research are presented.
J800 Advanced Microbiology (cr. arr.)* P: consent of instructor. The approach to problems in microbiology, including the application of techniques of bacteriology, genetics, immunology, mycology, parasitology, virology, and zoology.
J802 Introduction to Research (2 cr.) P: consent of instructor. Laboratory research instruction in microbiology and immunology. Purpose is to introduce students to three different research programs in microbiology and/or immunology.
J805 Molecular Immunology (3 cr.) P: B500 or equivalent; consent of instructor. Characterization of immunologically relevant molecules in terms of molecular genetics, synthesis and assembly, structure-function and evolutionary relationships, and functional roles in immune responses. Entities to be considered include members of the immunoglobulin superfamily and functionally associated molecules.
J806 Immunochemistry: Laboratory (cr. arr.) P: J805 C. Antigen preparation; separation and purification of antibodies; modern methods of antibody determination and analysis.
J807 Current Topics in Immunology (2 cr.) P: graduate standing, J805 or J840 or equivalent or consent of instructor. Discussion and review of current literature in selected topics in immunology. Emphasis on molecular and cellular events in lymphocyte activation and regulation. Topic varies from year to year. May be repeated for credit.
J810 Research in Microbiology (cr. arr.)* P: consent of instructor. Data obtained in this course may be used to meet the thesis requirements for graduate degrees.
J817 Biology and Chemistry of Fungi (3 cr.) P: BIOC B800 or equivalent. Current taxonomy, ultrastructure, metabolism, and genetics of slime molds and higher fungi, including those pathogenic for humans.
J821 Microbial Pathogenicity (3 cr.) This course will consider in detail the determinants of microbial virulence and the mechanisms of host responses to infection and how these two factors interact in the pathogenesis of infectious diseases.
J822 General and Medical Microbiology (3 cr.) Lectures covering the biology of various pathogenic organisms such as bacteria, viruses, fungi, and parasites, their role in human disease with emphasis on determinants of microbial virulence, the mechanisms of host responses to infection, and the role of these factors in the pathogenesis of disease.
J826 Bacteriology (3 cr.) P: J601 or J822 or their equivalent and consent of instructor. General concepts of bacteriology.
J828 Virology: Lecture (3 cr.) P: BIOC B500 or equivalent and consent of instructor. Basic biological principles of viruses; agents causing diseases in animals, including humans; interactions of animal viruses with their host cells in tissue culture.
J829 Current Topics in Molecular Genetics of Microorganisms (2 cr.) P: graduate standing, J821, J828 or G865, consent of instructor. In-depth study of a specific topic in contemporary molecular genetics of microorganisms. Topic varies; may be taken for credit more than once.
J830 Seminar in Microbiology (1 cr.) P: consent of instructor. Provides students with background and practical experience in communication of their research.
J837 DNA Repair, Mutation, and Recombination (3 cr.) P: consent of instructor. The molecular biology of genetic repair, mutation, and recombination; emphasis on functional capabilities of the processes that exist, how they were discerned, and their significance in the wider context of the molecular cell.
J838 E. coli Genetics Laboratory (1-3 cr.) P: relevant academic experience and consent of instructor. Bacterial cultures, mutagenesis, transformation, bacteriophage, strain construction, and phenotype assays; individual projects combining in vitro and in vivo recombination, restriction-electrophoresis analysis of plasmids and/or DNA sequencing.
J840 Mechanisms of Immune Regulation (2 cr.) P. consent of instructor. A current overview of the cellular mechanisms which regulate immune responses. Topics include cells and cytokines involved in antigen presentation, lympocyte activation and function, development, and tolerance.
J842 Neoplastic Determinants (2 cr.). P: G865, G817 or equivalent and consent of instructor. Focus on the genetic basis of the cancer phenotype. Consider effects of DNA sequence mutations, chromosomal rearrangements, and/or introduction of new genetic information on DNA repair, oncogene products and tumor suppressors. Intra- and intercellular consequences of these discrete alterations will be included.
J854 Hematopoiesis (2 cr.) P: G817, G865, and consent of the instructor. Principles of blood cell formation, including the regulation of production, biologic function, and cell culture and recombinant DNA technologies that contribute to our understanding. Stem cells, growth factors, cytokine envolvement, gene transfer/gene therapy and clinical applications.
J959 Oral Microbiology (1-3 cr.) P: basic microbiology. Role of oral microorganisms in health and disease states of the host. Emphasis will be placed on the biological mechanisms involved in dental caries, periodontal disease, and specific microbial infections of the oral cavity.
J960 Oral Microbiology Seminar (1 cr.) P: basic microbiology. Current topics in the field of oral microbiology.
GRAD G817 Eukaroytic Cell Biology (2 cr.) P: one semester of biochemistry. Organization and function of subcellular structures. Intracellular coordination of cell activity: protein and RNA trafficking, chromatin dynamics, and intracellular processing of receptor mediated signals.
GRAD G865 Fundamental Molecular Biology (3 cr.) P: B800 or equivalent. Principles of molecular structure, function, and biosynthesis; core information regarding procaryotic and eukaryotic gene continuity and metabolic coordination; introduction to multicellular systems and problems.

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