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University Graduate School  
Kirkwood Hall 111 
Indiana University 
Bloomington, IN 47405 
(812) 855-8853 
Contact Graduate Office 


College of Arts and Sciences

Ernest Davidson

Departmental e-mail:

Departmental URL:

Graduate Faculty

Chancellors’ Professor
George Ewing (Emeritus)

Linda and Jack Gill Chair
Gary Hieftje

Robert and Marjorie Mann Chair
Ernest Davidson

Lilly Chemistry Alumni Chair
Milos Novotny

Distinguished Professors
Kenneth Caulton, Ernest Davidson, Frank Gurd (Emeritus), Gary M. Hieftje, Ronald Hites (Public and Environmental Affairs), Milos Novotny, Peter Ortoleva (Geological Sciences), Charles Parmenter, Victor Viola

Herman T. Briscoe Professor
Dennis Peters

Earl Blough Professor
George Christou

Adam Allerhand, Edward Bair (Emeritus), Russell Bonham (Emeritus), Ernest Campaigne (Emeritus), Marvin Carmack (Emeritus), Jack Crandall, Harry Day (Emeritus), Joseph Gajewski, Stanley Hagstrom (Emeritus, Computer Science), W. Terry Jenkins (Emeritus, Biochemistry and Molecular Biology), Peter Langhoff, Lynne Merritt (Emeritus), Lawrence Montgomery, James Reilly, John Richardson (Biochemistry), V. Jack Shiner Jr. (Emeritus), Lee Todd (Emeritus), Rupert Wentworth (Emeritus), David R. Williams

Associate Professors
David Clemmer, Glenn Martyna,* Romualdo de Souza, Theodore Widlanski, Josef Zwanziger

Senior Scientist
John Huffman

Assistant Professors
Donald Burke,* Shuming Nie,* Martha Oakley,* Martin Stone,* Jeffrey Zaleski*

Adjunct Professors
Steven Girvin (Physics)

Graduate Advisor
Professor Jack K. Crandall, Chemistry Building C121, (812) 855-2069

Degrees Offered
Master of Science, Master of Arts for Teachers, and Doctor of Philosophy. The department also participates in the biochemistry, chemical physics, and molecular and cellular biology programs.

Fields of Study
Analytical, biological, inorganic, organic, and physical chemistry.

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Special Department Requirements

(See also general University Graduate School requirements.)

Admission Requirements
Undergraduate degree in chemistry, physics, mathematics, or the biological sciences. Students with undergraduate degrees in other areas of the physical sciences or engineering are also encouraged to apply. Students are admitted to the program only with the approval of the Chemistry Graduate Admissions Committee.

At least a B (3.0) average in work for the advanced degree. Grades below C (2.0) are not counted toward the completion of degree requirements but will be counted in determining a student’s grade point average.

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Master of Science Degree

This degree may be conferred upon the holder of a bachelor’s degree or master’s degree in another discipline.

Course Requirements
These requirements are flexible and are planned and approved by the graduate committee. A minimum of 30 credit hours in chemistry is required. At least 9 credit hours of course work in the major field offered in fulfillment of the M.S. degree must be in courses numbered 500 or above (excluding thesis work).


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Master of Arts for Teachers Degree

The M.A.T. program permits a secondary school teacher with minimum training in chemistry to achieve certification for the teaching major in chemistry in the secondary school. Teachers already holding such certification may strengthen their training by taking advanced lecture and laboratory work in chemistry. Students with B.A. or B.S. degrees in chemistry, but with no education courses, may complete requirements for a secondary Indiana teaching certificate and strengthen their chemistry training.

Admission Requirements
Eighteen (18) credit hours of chemistry, including one semester each of general, quantitative, and organic chemistry. Deficiencies must be removed without graduate credit. Continuance in the program will depend upon the results of a qualifying examination taken after either one semester or one summer in the program.

General Requirements
A total of 36 credit hours, of which a minimum of 20 credit hours must be in courses in chemistry which carry graduate credit. A maximum of 6 credit hours of undergraduate courses may be applied toward the M.A.T. degree. For a student having an unusually strong undergraduate background in chemistry, e.g., a B.S. degree, some of the required 20 credit hours in advanced chemistry courses may be in other areas of science and mathematics, if approved in advance by the graduate advisor. A student completing the requirements for the M.A.T. degree in chemistry must also have met the requirements for certification for a teaching major in science in the secondary school. Consult Education Student Services (Wright Education Building 1064, (812) 856-8511) for details.

Lecture-Course Requirements
Twelve (12) credit hours, distributed as follows: 6 credit hours in one of the five fields listed above and 3 credit hours in each of two of the remaining four. Lecture courses may be selected from those at the 500 level or above and from any of the following undergraduate courses: analytical, C317, C318; biological, C481, C483, C484, C485; inorganic, C430; organic, C342, S342, C443; physical, C360, C361, S361, C362, S362, C460.

Laboratory-Course Requirements
Two (2) credit hours chosen so that the student’s total background in advanced laboratory courses will include credit in three different fields. The following, and comparable courses taken elsewhere, will qualify: C315, C335, C344, S344, C364. Credit may be received for C509 if it is taken in a field in which a 500-level lecture course has been taken or is being taken concurrently.

Additional courses in chemistry at the 400 level or above to give a total of at least 20 credit hours (including course work in the above two categories). Up to 16 credit hours in courses at the 300 level or above in mathematics, biological sciences, physical sciences, or education carrying graduate credit.

Final Examination
Either oral or written or both.

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Master of Library Science/Master of Information Science Degree Information Specialist (Chemistry)

Offered by the School of Library and Information Science. Students in this joint program receive the Master of Library Science degree or the Master of Information Science degree and are certified as information specialists in chemistry.

Admission Requirements
Bachelor’s degree in chemistry or the equivalent.

Course Requirements
Three of the four common core courses in SLIS (L503, L505, L507, L509); Chemistry C400, C401, C402; and the core requirements for either the M.L.S. or the M.I.S. For further details, consult the graduate advisor in the School of Library and Information Science.

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Doctor of Philosophy Degree

The program leading to the Ph.D. degree emphasizes the attainment of a high level of competency in a specialized area of chemistry, but also requires the development of broad knowledge and experience. By the time the degree is earned, the student should show promise of becoming a capable and independent investigator in chemistry. The major emphasis for the Ph.D. is on research while in residence on the Bloomington campus. Research should be the student’s greatest challenge and the focus of the major portion of his or her energy. The student’s attitude toward and progress in research is a most important factor in graduate committee decisions.

Course Requirements
A total of 90 credit hours, of which at least 24 credit hours must be in course work. Students may major in analytical, biological, inorganic, organic, or physical chemistry; these fields are also acceptable as minors. Doctoral students majoring in a field of chemistry are required to complete a minimum of 12 credit hours of course work in that field, following a sequence of courses approved by their advisory committee.

A doctoral student in chemistry can choose to minor in a field of chemistry or can elect to minor in some other department. In the latter case, the requirements are specified by the minor department. Students electing to minor within the department must complete a minimum of 6 credit hours in one specific area of chemistry other than the major area. The course work comprising an inside minor must be approved by the advisory committee.

All doctoral students in chemistry are required to enroll in C500 Introduction to Research during their first year of study.

Foreign-Language/Tool-Skill Requirement
The department has no formal foreign language or tool-skill requirement, but Ph.D. advisory committees may consider such courses essential for individual students.

Qualifying Examinations
To remain in good standing, students must pass monthly cumulative examinations at the prescribed rate: one by the end of the second semester, three by the end of the third semester, and five by the end of the fourth semester. At least four examinations passed must be in the student’s major field. In the fifth semester, students meet with their advisory committees to review past performance in both the major and minor areas and to evaluate plans for completing the Ph.D. Current information concerning probation, termination, and reinstatement policies may be obtained from the departmental graduate office.

Final Examination
Usually oral, covering dissertation, major, and minors.

Ph.D. Minor in Chemistry
Students from other departments who wish to minor in one of the five fields of chemistry (analytical, biological, inorganic, organic, or physical) must complete at least 6 credit hours of graduate course work in that area with an average of B (3.0) or above.

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C315 Chemical Measurements Laboratory I (3 cr.)
C317 Equilibria and Electrochemistry (2 cr.)
C318 Spectrochemistry and Separations (2 cr.)
C335 Inorganic Chemistry Laboratory (1-3 cr.)
C341-C342 Organic Chemistry Lectures I-II (3-3 cr.)
C343-C344 Organic Chemistry Laboratory I-II (2-2 cr.)
C360 Introductory Physical Chemistry (3 cr.) Not for M.S. or Ph.D. students in chemistry.
C361 Physical Chemistry of Bulk Matter (3 cr.)
C362 Physical Chemistry of Molecules (3 cr.)
S362 Physical Chemistry of Molecules, Honors (3 cr.)
C364 Introduction to Basic Measurements (3 cr.)
C400 Chemical Information Sources and Services (1 cr.)
C401 Computer Sources for Chemical Information (1 cr.)
C402 Current Topics in Chemical Information (1 cr.)
C405 Principles of Chemistry (1-3 cr.) For teachers of high school chemistry; offered in summer session only. May be repeated.
C406 Lecture Demonstration Techniques in Chemistry (1 or 2 cr.) Nonmajors only.
C430 Inorganic Chemistry (3 cr.)
C460 Nuclear Chemistry (3 cr.)
C483 Biological Chemistry (3 cr.)
C484 Biomolecules and Catabolism (3 cr.)
C485 Biosynthesis and Physiology (3 cr.)
C500 Introduction to Research (2-6 cr.; 6 cr. max.) Objectives and techniques of chemical research. Assignment to research problem to be completed during two semesters.
C501 Chemical Instrumentation (4 cr.) Electronics as applied to chemical instrumentation; design and construction of instruments used in chemical research, analysis, recording, and control; maintenance and practice in modification to meet special needs.
C502 Spectroscopic Methods in Inorganic Chemistry (3 cr.) P: C361. Chemical applications of group theory and the elucidation of structure and bonding in inorganic molecules and complexes by vibrational, nuclear magnetic resonance, Mossbauer and electronic absorption spectroscopy.
C503 Spectrometric Methods of Structure Determination (3 cr.) P: graduate standing. Elucidation of molecular structure utilizing IR, UV, and NMR spectroscopy, mass spectrometry, and other methods.
C506 Biogeochemistry (3 cr.) The formation and processing of organic material in natural environments. Microbiology of sediments. The global biogeochemical cycles of carbon, nitrogen, and sulfur. Geochemistry of organic materials. Organic geochemical evidence of evolutionary events.
C509 Special Laboratory Problems (1-5 cr.) Nonmajors only. P: 8 credit hours of chemistry toward graduate degree, consent of instructor. P or C: 500-level lecture course in research field. Participation in scientific research to gain understanding of its philosophy and techniques.
C511 Advanced Analytical Methods I (4 cr.) Theory and practice of analytical separation techniques and analytical spectroscopy; chromatographic methods of separation, fundamentals of gas and liquid chromatography, overview of spectroscopic instrumentation, atomic and molecular spectroscopy for analysis.
C512 Advanced Analytical Methods II (4 cr.) Theory and practice of electrochemical (potentiometric and voltammetric) methods of analysis; introduction to analytical chemistry of the elements and statistics for analytical chemistry.
C540 Advanced Organic Chemistry (3 cr.) P: C362, C342. Valence and molecule structure, electronic interpretation of organic reactions, stereochemistry.
C543 Organic Reactions (3 cr.) Synthesis of organic compounds, degradation reactions, selected topics in organic reactions.
C561 Atomic and Molecular Quantum Theory (3 cr.) P: graduate standing or consent of instructor. Elements of quantum theory, solution of elementary problems with chemical applications, approximate methods, atomic structure, molecular symmetry and normal vibrations, the molecular orbital description of molecules.
C562 Computational Quantum Chemistry (3 cr.) P: C561 or consent of instructor. Electronic structure theory at the Hartree-Fock and semiempirical levels, computer calculations on elementary systems, elements of group theory and linear vector spaces, electron correlation, structure of potential surfaces.
C566 Molecular Optical Spectroscopy (3 cr.) P: C561 or consent of instructor. Interaction of radiation with matter. Spectroscopic probes of the rotational, vibrational, and electronic structure of molecules. Advanced laser methods.
C567 Chemical Statistical Mechanics (3 cr.) P: graduate standing or consent of instructor. Introduction to equilibrium and nonequilibrium many-body systems using ensemble techniques. Emphasis on molecular systems and systems undergoing chemical transformation or transport. Both qualitative and rigorous approaches.
C568 Advanced Statistical Mechanics (3 cr.) P: C567 or consent of instructor. Selected topics such as pair correlation functions in classical liquids, laser and reaction-transport, nonequilibrium phenomena, critical phenomena, reaction rates, condensed media, NMR, precipitation and polymer kinetics, Green’s function methods and computational methods.
C580 Medical Biochemistry (3 cr.) Biochemistry for medical students, emphasizing structure-function relationships of cellular components and biosynthesis and degradation of simple and complex cell constituents as well as regulation of metabolic pathways. Includes biochemical basis for genetic continuity and expression of hereditary characteristics.
C581 Function and Structure of Macromolecules (3 cr.) P: C483 or C484 or equivalent. Structure and conformation of proteins and nucleic acids: thermodynamics and kinetics of biochemical reactions.
C582 Enzymology and Intermediary Metabolism (3 cr.) P: C581 or consent of instructor. Chemistry of enzymatic reactions; coenzymes; cell structure; metabolism of carbohydrates, lipids, and amino acids; biological oxidation; metabolic regulation.
C583 Physiological Biochemistry (3 cr.) P: C483. To develop a sound and rigorous biochemical background for students in medicine and allied health sciences; biochemistry of physiological and pathological processes; role of heredity and environmental factors; effects on macromolecules, macromolecular aggregates, and cells.
C584 Biosynthesis of Macromolecules (3 cr.) P: C581 or L502. Biosynthesis of complex polysaccharides, nucleic acids, and proteins; their specification, regulation, and control.
C585 Structure and Function of Biological Membranes (3 cr.) P: C581 or consent of instructor. Chemistry and biology of lipids and membrane proteins.
C611 Electroanalytical Chemistry (1.5-3 cr.) Theory and practice of electrochemical techniques (such as cyclic voltammetry, chronocoulometry, stripping analysis, thin-layer electrochemistry, and spectroelectrochemistry) used for analysis and for the characterization of inorganic and organic systems. (May be offered in alternate years.)
C612 Spectrochemical Methods of Analysis (1.5-3 cr.) New instrumentation and techniques employed in spectrochemistry; in-depth treatment of commonly used spectrochemical methods. (May be offered in alternate years.)
C613 Mass Spectrometry and Stable Isotopes (1.5-3 cr.) Topics in mass spectroscopic instrumentation and applications and in the natural chemistry of the stable isotopes of C, H, N, O, S, and rare gases. (May be offered in alternate years.)
C614 Chromatography (1.5-3 cr.) Theoretical and practical aspects of chromatographic methods of separation; fundamentals of gas and liquid chromatography, related instrumentation, and selected applications. (May be offered in alternate years.)
C615 Bioanalytical Chemistry (1.5-3 cr.) Survey of modern analytical techniques, including spectrochemical, electrochemical, and separation methods, used in biochemical analysis and their applications. (May be offered in alternate years.)
C616 Surface Analysis and Surface Chemistry (1.5 cr.) An overview of the modern instrumental techniques of surface analysis will be presented, together with a survey of their applications to solve surface chemical problems. Topics include electron and ion spectroscopies, SIMS, LEED, thermal desorption spectroscopy, surface electron and ion microscopies, catalysis, microelectronics fabrication, and corrosion.
C618 Special Topics in Analytical Chemistry (1-3 cr.) P: consent of instructor. Special topics of current interest in analytical chemistry. (May be repeated.)
C619 Seminar: Analytical Chemistry (1 cr.) P: consent of instructor. Individual student seminars covering new methods or applications of chemical analysis or characterization. Required of all analytical chemistry majors.
C630 Structure and Bonding (3 cr.) P: C502 and C561. Applications of quantum mechanics to the electronic and geometric structure of inorganic molecules. Advanced ligand field and molecular orbital theories. The Jahn-Teller effects and orbital symmetry studies of stereochemistry. Inorganic photochemistry. (May be offered in alternate years.)
C632 Structure, Function, and Spectroscopy of Metal Ions in Biological Systems (3 cr.) Introduction to the field of bioinorganic chemistry and spectroscopic methods for determining structure/function relationship of metal ions in biology. Emphasis on oxygen carriers, metal ion transport and storage, as well as oxidoreductases involved in oxygen, hydrogen, and nitrogen metabolism. A discussion of electron transfer proteins, photosystems, and the role of metals in medicine will also be included.
C633 Inorganic Chemistry of Main Group Elements (3 cr.) The syntheses, structure, and industrial application of compounds and materials in which main group elements play a major role. All elements except the d-block transition metals are included as main group elements. This includes the f-block lanthanides and actinides as well.
C634 Transition Metal Chemistry (3 cr.) Survey of the properties of the transition metals with emphasis on common oxidation levels, coordination geometries and compounds with “classical” ligands; “hard” and “soft” acids and bases; d-orbitals and their energies in different geometries; formation constants and the Chelate Effect, the Jahn-Teller theorem; low-, intermediate-, and high-spin systems; mixed valency; metal-ligand multiple bonding, metal-metal bonds; coordination clusters and their biological relevance.
C635 Mechanisms of Inorganic Reactions (3 cr.) Analysis of the experimental and theoretical basis for our understanding of the reactions associated with main group and transition metal ions and inorganic reagents in solution. Classes of reactions include ligand substitutions, redox reactions, electron transfer reactions, reactions within the coordination sphere of metal ions including catalysis by photochemical and electrochemical activation.
C636 Organometallic Chemistry and Catalysis (3 cr.) Synthesis and reactivity of organo-main group and transition metal compounds, including application to organic synthesis. Predictive principles and generic C-C and C-H bond-forming reactions, including hydrogenation, coupling, addition to olefins or alkynes, and metatheses. These reactions are also extended to reactions on surfaces and solid-state processes.
C637 Physical Methods in Structural Chemistry (3 cr.) Application of X-ray diffraction, dynamic NMR and mass spectroscopy to structural and mechanistic problems throughout the periodic table, with emphasis on what techniques are optimal for particular questions, as well as the potential weaknesses of each.
C638 Seminar: Inorganic Chemistry (1-3 cr.) P: consent of instructor. Topics not ordinarily covered by regularly scheduled courses, such as boron hydrides, X-ray diffraction, metal-metal bonds, bioinorganic chemistry, platinum metals chemistry, inorganic photochemistry, etc. (May be offered in alternate years.)
C639 Characterization of Paramagnetic Molecules (3 cr.) Definitions of diamagnetism, paramagnetism, magnetization and magnetic susceptibility; the Curie Law; orbital angular momentum; the Van Vleck equation; zero-field splitting; exchange interactions in dinuclear and polynuclear metal clusters. Basic concepts of paramagnetic NMR; spin delocalization mechanisms and isotropic shifts; contact and dipolar contributions. EPR of transition complexes; g value anisotrophy as a function of coordination geometry.
C643 Organic Natural Products (3 cr.) P: C540, C543; or consent of instructor. Synthesis and chemical-physical analysis of the structure of alkaloids, antibiotics, bacterial metabolites, plant pigments, steroids, and terpenes. (May be offered in alternate years.)
C644 Physical Organic Chemistry (1-3 cr.) P: C342, C362. Application of physical-chemical techniques to the study of structure and mechanism of reaction of organic compounds.
C648 Seminar: Organic Chemistry (1-3 cr.) P: consent of instructor. Recent developments in such areas as sulfur compounds, heterocycles, stereochemistry, polymers, and synthesis. (May be repeated.)
C668 Seminar: Physical Chemistry (1-3 cr.) P: consent of instructor. Topics such as chemical applications of matrix algebra and group theory, digital computing techniques, solid state chemistry, high temperature processes, electrochemistry, theory of solutions, spectroscopy, and surface chemistry. (May be repeated.)
C681 Structure and Reactivity of Proteins (3 cr.) P: C581. Supplements and extends C581; emphasis on chemical synthesis and modification; stability and thermodynamics; complex proteins such as lipoproteins, metalloproteins, and glycoproteins.
C682 Advanced Enzymology (3 cr.) P: C581, C582, or consent of instructor. This course supplements the basic enzymology offered in C582. The course emphasizes the kinetics of enzymic reactions, mechanisms of organic catalysis, and current research methods in enzymology. There will be two lectures and one student presentation each week.
C684 Metabolism of Complex Molecules (2-3 cr.) P: C581, C582. An advanced course dealing with the metabolism and regulation of complex biological structures and events, among them lipids and lipoproteins; polysaccharides; contraction, motion, and division; electron transport and energy transduction, and the regulation of highly integrated cellular functions.
C687 Seminar: Advanced Topics in Biochemistry (1-3 cr.) P: consent of instructor. Topics vary yearly and include the following: physio-chemical techniques in the study of macromolecules; experimental methods in enzymology; organic chemistry of enzymatic reactions and enzyme models; conformational properties and macromolecules.
C688 Seminar: Biological Chemistry (1-3 cr.) P: consent of instructor. Recent advances in such areas as biological oxidations, energetics and equilibria, hormones, and nutrition. (May be repeated.)
C810 Research: Analytical Chemistry (cr. arr.)*
C830 Research: Inorganic Chemistry (cr. arr.)*
C840 Research: Organic Chemistry (cr. arr.)*
C860 Research: Physical Chemistry (cr. arr.)*
C880 Research: Biological Chemistry (cr. arr.)*

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