G667  Tools and Techniques in Translational Research (3 cr.)  This course is offered in the fall semester and provides the advanced student with an understanding of the basic technologies and techniques used in translational research today. Key to this training is understanding how and when to use these technologies, and how to interpret their results and pitfalls. The trainees develop an understanding of the components for protecting human subjects, and how to move a novel concept from the lab to a patient. Finally, the student will understand how to identify and measure target endpoints in patients, and how to assemble a multi-disciplinary team to conduct translational research. The course will uses a case-based approach whereby specific technologies and problems are demonstrated in readings drawn from the textbook. The course is supported by the Indiana C.T.S.I. Course Director: R. Mark Payne. (Fall Semester) 
G668  Quantitative Aspects of Translational Research (3 cr.)  An interdisciplinary seminar series offered in the spring semester. Targeted toward the advanced graduate student and clinical or research based postdoctoral fellows, it will provide a forum for both Level 1 (bench to bedside) and Level 2 (clinical studies to practice) translational researchers to work together in learning both the key concepts and principles required to develop medically relevant solutions. Lecturers will represent the multiple disciplines with a stake in dealing the various aspects of disease; thus, providing students with a better global understanding. Course Director: Robert Bies. (Spring Semester)

G504/G505/P555  Research Ethics (Responsible Conduct of Research - R.C.R.) (1-3 cr.)  All M.S. students must enroll in coursework related to R.C.R. if they have not already done so.

1. G504   Introduction to Research Ethics (2-3 cr.)  More intensive course than G505. Taught by the Department of Medical and Molecular Genetics and The IU Center for Bioethics. Course Director: Kimberly Quaid de Cordon. (Fall Semester)
2. G505   Introduction to Research Ethics (1 cr.) Offered in the fall semester, G505 includes lecture and small group discussion formats and covers important issues in biomedical research, such as: 1) Scientific misconduct, 2) Conflict of interest, 3) Animal rights and welfare, 4) Ownership of data, intellectual property, and copyright management, 5) Authorship and scientific manuscripts, and 6) Informed consent and human subjects. Course Director: Michael J. Klemsz. (Fall Semester)
3. PHIL P555   Ethical and Policy Issues in International Research (3 cr.)  If students are contemplating international research, they may opt for this course. This course examines ethical and policy issues in the design and conduct of transnational research involving human participants.  Topics discussed include: economic and political factors; study design; the role of ethics review committees; individual and group recruitment/informed consent; end of study responsibilities; national and international guidelines. Course Director: Eric M. Meslin. (Fall Semester)

B651  Biostatistics I (or approved equivalent) (3 cr.)  B651 is an introductory level biostatistics course designed for healthcare professionals. It is the first in the B651 and B652 series on biostatistics methodology. The course covers topics such as data description and presentation techniques, probability and probability distributions, sampling distributions, statistical inferences from small and large samples, analysis of categorical data, analysis of variance, correlation and simple linear regression analysis. Upon completion of the course, students will achieve a basic understanding of the concepts and techniques of data description and statistical inferences. Students will also acquire a working knowledge of SAS, a commonly used statistical computation program. Students will be able to understand and interpret the statistical analyses in research articles published in medical journals. Course Director: B. Katz. (Spring and Fall semesters)

or

B652  Biostatistics II (or approved equivalent) (3 cr.)  B652 is an advanced applied biostatistics course designed for students with an interest in the health sciences. Students are expected to have completed at least one semester course of basic biostatistics. Knowledge of probability and probability distributions, concepts of estimation and hypothesis testing are assumed. Topics covered in this course include multiple linear regression, multi-factor analysis of variance, analysis of covariance, analysis of repeated measures, logistic regression model, and survival analyses. Upon completion of the course, students are expected to understand the appropriate statistical models for various outcomes and be able to interpret results using statistical techniques covered in this course. Course Directors: S. Gao & P. Monahan.

or

B551 Biostatistics-Public Health I (or approved equivalent) (3 cr.) B551 is an introductory level biostatistics course designed for healthcare professionals. The course covers topics such as data description and presentation techniques, probability and probability distributions, sampling distributions, statistical inferences from small and large samples, analysis of categorical data, analysis of variance, correlation and simple linear regression analysis. Upon completion of the course, students will achieve a basic understanding of the concepts and techniques of data description and statistical inferences. Students will also acquire a working knowledge of SPSS, a commonly used statistical computation program. Students will be able to understand and interpret the statistical analyses in research articles published in medical journals.

N801  Techniques of Effective Grant Writing (or approved equivalent) (3 cr.)  This is an intensive course / workshop designed to teach fellows and graduate students how to write and review an N.I.H. application. Trainees will write an N.R.S.A., R03, or K-award application. Course Directors: Paul Lysaker. (Fall Semester).

Electives (3-7 cr.)

Example electives include graduate level courses in more advanced biostatistics, epidemiology, clinical pharmacology, genetics, molecular biology, and computer sciences.  However, enrollees may select electives from the entire offering of graduate courses at both Indiana University and Purdue University at Indianapolis as well as IU at Bloomington.  Must be approved by Program Director.

Requirements for M.S. in Translational Science for people with clinical background (i.e., M.D.)

G669  Mentored Basic Science/Translational Research (1-9 cr.)   This mandatory course requires the student to construct an organized translational research project under dual mentorship (M.D. and Ph.D.) by faculty. The capstone experience is the completion of a grant in the N.I.H. format suitable for peer-review and presentation before one’s peers. This course will be conducted in the fall, spring, and summer terms, graded by faculty, and should be in a format supporting submission to a funding organization. Course Director: R. Mark Payne

G670  Thesis in Translational Research (3 cr.)  This mandatory course requires the student to complete a research thesis based on their mentored basic science/translational research project. Course Director: R. Mark Payne

Requirement for M.S. in Translational Science for people with Basic Science background (i.e., Ph.D.)

G671  Clinical Rotations for Translational Scientists and Engineers (3-9 cr.)  Students rotate in pairs through all rotations, and an effort is made to only have two students on each rotation at a time to maintain a high quality experience. These courses serve to both introduce the students to clinical medicine, and acclimatize them to the language and environment of hospital-based and out-patient medical care. Designed as practicums, these courses are particularly aimed at non-clinician scientists intending to conduct translational research.

Ph.D. Minor in Translational Science

This is a 12-credit program which focuses on biomedical research techniques—how to translate a basic science discovery into a treatment or diagnosis protocol that physicians and clinicians can use to treat patients. All students expressing interest will be encouraged to speak with the program director or one of the Executive Committee members. The minor program will be approved by the student’s advisory committee, which will take into consideration the student’s total didactic experience. The advisory committee may approve additional and/or substitution of appropriate courses to complete the degree requirements. The minor representative on this Committee will be selected from outside the student’s major department.

Courses
(See course descriptions above.)

G667   Tools and Techniques in Translational Research  (3 cr.)  
G668   Quantitative Aspects of Translational Research (3 cr.)
G504/G505/P555  Research Ethics (Responsible Conduct of Research - R.C.R.) (1-3 cr.)
G651   Biostatistics I (or approved equivalent) (3 cr.)

or

G652   Biostatistics II (approved equivalent) (3 cr.)
Electives: Must be approved by Program Director (up to 3 cr.)