Department of Biochemistry and Molecular Biology

Chair: Professor Zhang

Medical Courses

B800 Medical Biochemistry (3 cr.) Biochemistry for medical students. Structure and function of biological molecules, regulation of cellular processes by nutrients and hormones, biochemical and molecular basis of disease. Designed to develop the knowledge base for Competency III “Using Science to Guide Diagnosis, Management, Therapeutics and Prevention.” Harris

X604 Concepts of Health and Disease (4 cr.) A multidepartmental, interdisciplinary course which integrates concepts of the first-year medical curriculum using the problem-based learning approach. Students work in small groups facilitated by faculty to interpret clinical cases and integrate basic science and clinical science concepts. Designed to assess the proficiency at Level I for portions of the competencies. Staff

X804 Cellular and Molecular Biology (3 cr.) Cellular and molecular biology that emphasizes the structural organization, biochemistry and molecular biology of cells. Includes cellular processes, development and differentiation and their relationship to medicine. Harrington

Graduate Courses

The courses listed below are primarily intended for students seeking the M.S. or Ph.D. degree in biochemistry, or the combined M.D. and graduate degrees.

B500 Introductory Biochemistry (3 cr.) Structures of carbohydrates, proteins, lipids and nucleic acids. Basic principles of enzyme catalysis, protein synthesis, intermediary metabolism and nutrition. Skalnik

B807 Structural and Chemical Biology (2 cr.) This course will explore the fundamentals of macromolecular structure and chemical biology with an emphasis on the underlying principles of interactions between macromolecules and small molecules. Topics will include structural, computational, and high-throughput screening approaches to drug development, and the use of chemical tools for understanding biological processes. Georgiadis and Zhang

B848 Bioinformatic Applications to Proteomics and Genomics (2 cr.) Modern biology has been transformed by massive databases containing whole-organism nucleic acid sequences, whole-organism information on genetic networks, protein networks, and sets of small molecules. This course focuses on these databases and on the computational tools used to assemble these databases and to ask questions of them. Dunker

B868 Advanced Molecular Biology (2 cr.) Advanced topics in molecular biology, genetics, immunology, and pathophysiology of diabetes and obesity. DePaoli-Roach and Lee

B890 Seminar (1 cr.) Students will enroll each semester and present one seminar per year. DePaoli-Roach

G805 Diabetes and Obesity (2 cr.) Biochemistry, cell biology, molecular biology, genetics, immunology and pathophysiology of diabetes and obesity. Thurmond and Considine

G810 Concepts of Cancer Biology: Signaling gone awry (2 cr.). Fundamentals of cancer biology; the signaling events that regulate cell growth, survival and differentiation; how mutation!dysregulation of signaling molecules leads to cancer. Quilliam and Roman

G817 Advanced Cell Biology (2cr.) Molecular mechanisms involved in intracellular organization and trafficking. Goebl

Biotechnology Training Program

A Graduate Certificate in Biotechnology is designed to train technicians for working in health-related industrial research laboratories, including those at the IU School of Medicine. The M.S. degree in Biotechnology aims to boost the research skills of individuals interested in health sciences research. Complete program information is available at the website:
http://www.indiana.edu/~gradschl/biotech Training

B500 Introductory Biochemistry (3 cr.) Structures of carbohydrates, proteins, lipids and nucleic acids. Basic principles of enzyme catalysis, protein synthesis, intermediary metabolism and nutrition. Skalnik

B821 Scientific Writing and Communication (1 cr.) Discussion and individualized instruction in the preparation of a research proposal and thesis in the Biotechnology track of the M.S. in Biochemistry and Molecular Biology. S. Sanghani

B822 Reearch in Biotechnology (1-3 cr.) The objective of the course is for the student to conduct new research for the thesis under the direction of a faculty research mentor and a director of a School of Medicine Core research facility. Staff

G823 Methods in Cell Biology (3 cr.) Discussion and laboratory instruction in modern methods for cell culture, imaging, flow cytometry and cell biology. S. Sanghani

G828 Concepts in Biotechnology (1 cr. each semester) Case studies exploring topics on the cutting edge of biotechnology and tutorials in biotechnology calculations. Bosron

G841 Methods of Protein Chemistry (3 cr.) Discussion and laboratory instruction in modern methods for protein purification, analysis of purity, peptide mapping, and amino acid sequencing. P. Sanghani

G890 Methods in Molecular Biology and Pathology (3 cr.) Basic principles and techniques in molecular biology and pathology. Particular emphasis will be on molecular techniques that can be used to study problems related to biochemistry and pathology. Lee

Graduate Electives

B800 Medical Biochemistry (3 cr.) Structure and function of biological molecules, regulation of cellular processes by nutrients and hormones, biochemical and molecular basis of disease. Harris and Staff

B803 Advanced Biochemistry (1-3 cr.) Tutorial instruction in biochemistry. Staff

B809 Advanced Organic Chemistry (1-3 cr.) Tutorial instruction in organic chemistry, as applied to biochemistry. Roeske

B811 Advanced Intermediary Metabolism (1 3 cr.) Tutorial instruction in specialized areas of metabolism. Harris and Roach

B814 Advanced Enzymology (1-3 cr.) Tutorial instruction in advanced enzyme isolation and kinetics.

B835 Neurochemistry (3 cr.) Metabolism of nervous system tissues. Neurochemical techniques. Simon

B836 Advanced Topics in Neurochemistry (2 cr.) Selected topics in neurochemistry dealing with the specialized functions of the nervous system. McBride and Simon

B842 Instrumentation and Methods of Analysis (3 cr.) Staff

B854 Introduction to Research in Biochemistry (1 cr.) Tutorial and laboratory instruction in biochemistry. Purpose is to introduce students in biochemistry to three different research programs. Staff

B855 Research (cr. arr.) Staff

B899 Senior Elective in Biochemistry (hrs. and cr. arr.) A variety of electives is offered within the department. Specific information on each elective is available in the Senior Elective Program Course Listing, which is updated and published in February of each year. These electives are offered in the Medical Center facilities and in approved programs in clinics and hospitals throughout the state. Staff

G804 Cellular and Molecular Biology (3 cr.) Cellular and molecular biology that emphasizes the structural organization, biochemistry and molecular biology of cells. Includes cellular processes, development and differentiation and their relationship to medicine. Wek

G901 Advanced Research (6 cr.) Research for graduate students who have over 90 credit hours. Goebl

G910 Advanced Molecular Biology Methods (3 cr.) Advanced theory and techniques in molecular biology. The focus of the course will be on techniques related to manipulation of cloned DNA for study of their expression, structure and function. DePaoli-Roach

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