Chair: Professor Sturek

Graduate Director: Professor Gallagher

Department E-mail: cellphys@iupui.edu

F499 Independent Research in Medical Physiology and Biophysics (1-4 cr.) Research for undergraduate students. Introduction to research methods and scientific investigation in cellular and medical physiology or biophysics. Research areas include neurobiology, neurophysics, cellular, respiratory, muscle, vascular or renal physiology and endocrinology. Staff

F613 Mammalian Physiology Lecture (5 cr.) Physiology course for medical students covering, neurophysiology, physiology of muscular activity, respiration, circulation, gastrointestinal physiology, excretion, metabolism, and endocrinology. Emphasis on basic physiological mechanisms and control systems but clinical application stressed. Tanner and Staff

X604 Concepts of Health and Disease (4 cr.) A multi-departmental, interdisciplinary course, which integrates concepts of the first year medical curriculum using a problem-based learning approach. Students work in small groups facilitated by faculty to interpret clinical cases and integrate basic science and clinical science concepts. Designed to assess the proficiency at Level I for portions of the competencies. Staff

X/G804 Cellular and Molecular biology (3 cr.) Cellular and molecular biology for medical students that emphasizes the structural organization, biochemistry and molecular biology of cells. Includes cellular processes, development and differentiation and their relationship to medicine. Wek and Staff

Graduate Courses and Electives

The courses listed below are primarily intended for students seeking the M.S. or Ph.D. degree in cellular and integrative physiology, or the combined M.D. and graduate degrees. Complete and current program information is provided in the departmental Web site: www.iupui.edu/~medphys/

F503 Human Physiology (4 cr.) P: introductory biology, organic chemistry, and physics. Graduate-level course in human physiology designed for students with no prior exposure to the discipline. Emphasis on basic physiological mechanisms of control with regard to membrane, neural, endocrine, reproductive, muscle, cardiovascular, respiratory, gastrointestinal, renal, and multisystems physiology. Peavy and Staff

F595 Advanced Physiology (1-15 cr.) P: consent of instructor. Special techniques in advanced areas of physiology.

F701 Research in Physiology (1-15 cr.) Original laboratory research required for fulfillment of M.S. or Doctoral degrees.

F702 Seminar in Physiology (1 cr.) Seminars delivered by invited international, national, and local speakers. Interactive, with question-and-answer period.

F705 Molecular and Cellular Physiology (4 cr.) P: undergraduate cell biology; R: biochemistry. Introduction to techniques, topics, and principles relevant to modern cellular physiology, molecular biology and cell biology. Students learn critical analysis of current scientific literature in an interactive setting, are introduced to internet data mining skills, and participate in tutorials, problem sets, and equipment demonstrations. Topics vary yearly, but have recently included cell adhesion molecules, epithelial function, muscle, leptin, and cellular ion homeostasis. Each topical unit discusses molecular physiology in health and disease. Kempson and Staff

F710 Cellular Physiology: From Molecules to Cells (4 cr.) P: undergraduate cell biology; R: biochemistry. Cellular and molecular underpinnings of modern physiology necessary for understanding cell and organ function including cellular and membrane architecture, membrane transport, signal transduction, gene expression, growth and development, cell excitability and contractility. The goal of this course is to provide an understanding of the cellular principles that are common to the function of all organs and tissues. Elmendorf and Staff

F711 Integrative Physiology: From Cells to Tissues (4 cr.) P: no formal prerequisites, although background in basic biochemistry and cell biology or cell physiology is recommended. Introductory physiology course for graduate students covering fundamental concepts of cellular and integrative physiology of tissues and organ systems. Basic physiology of the neural, musculo-skeletal, cardiovascular, respiratory, renal, endocrine, and gastrointestinal systems are covered. At the end of the course, students should have a basic understanding of the physiologic functions of cells, tissues and organ systems and should understand modern approaches for the measurement and interpretation of physiologic functions. Gunst and Staff

F780 Special Topics in Physiology (1-15 cr.) Tutorial instruction in physiology. Staff

GRAD G760 Epithelial Cell Biology (3 cr.) P: F710 and F711 or graduate-level physiology. An integrated approach to epithelial structure and function and the role of subcellular organization in organ physiology and pathophysiology.

GRAD G818 Integrative Cell Biology (3 cr.) P: F710 and F711 or graduate-level physiology. This course provides broad understanding of ways in which cells are organized and integrated into tissues. Emphasis is on the function of cells in neural/neuro-endocrine system, cardiopulmonary, renal, and immune systems and in cytomechanics. Modern approaches to the study of tissue function by analysis of cellular regulation will be emphasized. Hui and Staff

Focused Elective Courses

Elective courses taken by graduate students in all of the basic sciences who wish to enhance their knowledge of a specific area of physiology (F710 or basic cell biology course recommended; F711 or graduate-level physiology course required). Each course is composed of a 2-3 hour discussion each week for 4-5 weeks. These sessions are informal discussion of review and original research papers covering new technology and progress in each focus area. Demonstration of new laboratory technology relevant to the focus area is an integral part of some focus courses. Students are expected to prepare for each discussion or demonstration session. These courses are offered year-round; times and dates for courses are to be arranged with the instructor. Interested students should contact the graduate program director.

F703 Specialized Physiological Techniques (1 cr.) P: F710 and F711 or graduate level physiology and cell biology. Current research methods in cellular and molecular physiology, as applied to the study of macromolecular function, motility, cellular signaling, and membrane function. Topics, which will be announced each semester, could focus on the use of basic optical techniques and digital image processing or design and creation of genetically modified animal models.

F704 Cardiovascular Physiology (1 cr.) P: F710 and F711 or graduate-level physiology. This course is designed to give the student an in-depth understanding of selected topics in cardiovascular physiology. Emphasis is placed on discussion of current literature and critical analysis of experimental design to probe unanswered questions.

F707 Special Topics in Signal Transduction (1 cr.) This course will cover recent advances in the field of cellular signaling. For each topic, the students will prepare an overview and discuss two to three recent research papers.

F712 Physiology of the Circulatory System (1 cr.) P: F710 and F711 or graduate level physiology. Hemodynamic principles; cardiac regulation and vasomotor control; pressure pulses; cardiac output, work, and adaptation; special circulation.

F724 Physiology of Nerve (1 cr.) P: F710 and F711 or graduate level physiology. Excitation and conduction of the nerve impulse. Axoplasmic transport and nerve maintenance. Synaptic transmission and trophic control. Reflexes. Staff

F725 Muscle Macromolecules and Contraction (1 cr.) P: F710 and F711 or graduate-level physiology. Structure and function of various macromolecules involved in muscle contraction. The aspects covered include excitation-contraction coupling, regulation of myoplasmic free calcium level, the contractile machinery, and force generation. Comparison in skeletal, cardiac, and smooth muscles. Lectures and guided discussion of papers.

F734 Blood Gases and Respiration (1 cr.) P: F710 and F711 or graduate-level physiology. Pulmonary mechanics and gas exchange, gaseous transport and uptake by tissues, acid-base balance, central and reflex control of respiration, respiratory problems in altitude and deep-sea physiology, and modern techniques in respiratory physiology.

F752 Physiology of the Gastrointestinal System (1 cr.) P: F710 and F711 or graduate-level physiology. Mechanics of digestive tract; secretory mechanism of digestive glands; digestion and absorption of the major foodstuffs.

F765 Physiology of the Endocrine System (1 cr.) P: F710 and F711 or graduate-level physiology. Regulation of secretions of the endocrine glands, including neuroendocrine system, action of the hormones; roles of hormones in maintenance of a constant internal environment.

F772 Physiology of Body Fluids and Electrolytes (1 cr.) P: F710 and F711 or graduate-level physiology. Composition and distribution of body fluids and electrolytes; renal regulatory role; factors concerned with glomerular filtration rate and blood flow; tubular function; handling of organic and inorganic substances; chemistry and physics of the transfer of mechanism; role of hormones.

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