• PHAR–F 604 Pharmacology (120 hrs.) (6 cr.) Lectures, quizzes, laboratory. Required for sophomore medical students. Drugs classified as to site and mechanism of action; representative members of each class of drugs discussed; rational clinical uses emphasized; basic statistical techniques and their application to medical problems are introduced. The laboratory experiments illustrate typical actions of drugs. Student projects may be approved in lieu of part of laboratory. Richardson

Graduate Courses and Electives

The courses listed below are primarily intended for students seeking the M.S. or Ph.D. degree in pharmacology or toxicology, and for medical students seeking a combined M.D. and graduate degree. Complete program information is provided in the Graduate School Bulletin and/or departmental brochures.

• PHAR–F 598 Drugs, Diseases and Poisons (3 cr.) P: A course in basic biology or physiology equivalent to K324 or BIOL 501. Introductory course in pharmacology and toxicology primarily for senior undergraduate students. The course provides an overview of the molecular basis of drug action and pharmacological properties of several of the major drug groups used in medical science. Richardson

• PHAR–F 602 Pharmacology: Lecture (5 cr.) P: Biochemistry B800, Physiology F513, F614. Mode of action of drugs as a basis for therapy. Richardson and Faculty

• PHAR–F 801 Introduction to Research in Pharmacology and Toxicology (1–3 cr.) Application of basic laboratory methods to pharmacological problems. Consideration of theoretical principles, instrumentation, and applications. Faculty

• PHAR–F 813 Clinical Pharmacokinetics (3 cr.) Design and complete mathematical analysis of pharmacokinetic studies in humans. The clinical utility of pharmacokinetics will be stressed, but the course will also have definite value for those involved with drug studies in animals. Faculty

• PHAR–F 819 Chemical Carcinogenesis (3 cr.) This course examines the mechanisms by which chemicals cause cancer. Emphasis on the uptake, metabolism, cellular targets, and specific stage(s) of the cancer process affected by chemical carcinogens. Faculty

• PHAR–F 826 Seminar in Toxicology (1 cr.) Literature and research reports by students and faculty. Broustovetsky

• PHAR–F 836 Pharmacogenetics and Physiological Disposition of Drugs (3 cr.) Factors affecting the absorption distribution, metabolism, and excretion of drugs will be discussed in terms of environmental, biochemical, and physiochemical parameters. Pertinent literature will be reviewed and special problems discussed. Callaghan

• PHAR–F 830 Seminar in Pharmacology (1 cr.) Literature and research reports by students and faculty. Broustovetsky

• PHAR–F 838 Cellular and Molecular Toxicology (3 cr.) This graduate-level course deals with the study of the effects of toxic xenobiotics at the cellular, biochemical, and molecular levels. The course emphasizes the mechanisms through which toxic chemicals interact to evoke toxicological manifestations. Faculty

• PHAR–F 841 Advanced Topics in Toxicology (1–3 cr.) A continuing, nonrepeating series of lectures on advances in toxicology. Topics will examine metabolic, cellular, and molecular mechanisms by which toxic agents produce injury. Nass

• PHAR–F 843 Pharmacology of Cellular Transduction (3 cr.) This course focuses on mechanisms involved in cellular signal transduction ranging from the molecular biology of receptors to the role of transduction cascades in drug action. Students will participate extensively in discussion of issues. Nicol, Vasko, and Faculty

• PHAR–G 747 Principles of Pharmacology (1 cr.) This course is intended for incoming basic science doctoral graduate students in the School of Medicine Pharmacology and Toxicology programs or other interested graduate students. This course covers the basics of drug-receptor interactions, drug metabolism, pharmacogenetics, and pharmacokinetics. This course will include PowerPoint presentations and student presentations. Richardson

• PHAR–G 748 Principles of Toxicology 1 (1 cr.) This course will present the fundamental concepts of toxicology necessary to understand the effects of chemicals on human health. Cellular and molecular mechanisms involved in toxic responses elicited by pharmaceutical and environmental agents, activation and detoxification of drugs and chemicals, and the principles of carcinogenesis and mutagenesis will be presented. Wagner

• PHAR–F 850 Experimental Design Analysis in Pharmacology and Toxicology (1 cr.) P: F602. This course presents experimental methods and data analysis used in pharmacological and toxicological experimentation. Emphasis will be on experimental design. Cummins

• PHAR–G 754 Principles of Toxicology 2 (1 cr.) Xenobiotic-induced target organ toxicity will be discussed with respect to the biological and/or chemical factors that influence toxicity at a tissue site, the modes of action for producing damage, and the methodology used to measure injury. This course is designed to provide a foundation for understanding the complex interactions between toxicants and biological systems from a basic science approach. Nass

• PHAR–G 755 Principles of Toxicology 3 (1 cr.) The effects associated with specific classes of chemicals, including chemical agents that either demonstrate a great chance for injury and/or pose significant potential for human exposure will be presented. The chemical classes covered will include selective metals, solvents and alcohols, pesticides, plastics, and gases. Chou

• PHAR–F 812 Research in Toxicology (1–12 cr.) P: F602. Independent laboratory research to fulfill dissertation requirements. Faculty

• PHAR–F 825 Research in Pharmacology (1–12 cr.) This course is more advanced than the senior electives F803 and F806. Independent laboratory research for fulfilling the dissertation requirements. Faculty

• PHAR–F 899 Senior Elective in Pharmacology (arr. hrs.) (arr. cr.) A variety of electives are offered within the department. Specific information on each elective is available in the Senior Elective Program Course Listing, which is updated and published in February of each year. These electives are offered in the Medical Center facilities and in approved programs in clinics and hospitals throughout the state.

• PHAR–F 905 Review of Pharmacodynamics (arr. hrs.) (arr. cr.) Faculty