Courses for Medical Students

School of Medicine required courses are restricted to those medical students and graduate students whose departmental graduate programs require the courses. These students must also receive approval from the director of the Medical Sciences Program.

Anatomy

• ANAT–A 550 Gross Human Anatomy I (4 cr.) Study of the gross anatomy of the human, including regional dissections and radiographic and cross-sectional anatomy. Developmental and systemic anatomy, regional anatomy of the thorax, abdomen, pelvis, and perineum. Doubleday and O’Laughlin

• ANAT–A 551 Gross Human Anatomy II (4 cr.) P: A550. A continuation of A550. Developmental and regional anatomy of the extremities, the head, and the neck. Doubleday and O’Loughlin

• ANAT–A 560 Human Microscopic Anatomy (4 cr.) Microscopic study of the anatomy of the human. Tissue histology and embryology of each of the systems of the body. Foley and Mescher

Chemistry

• CHEM–C 580 Medical Biochemistry (3 cr.) A course emphasizing structure-function relationships of cellular components and biosynthesis and degradation of simple and complex cell constituents, as well as regulation of metabolic pathways. Includes biochemical basis for genetic continuity and expression of hereditary characteristics. Mazumdar and Walczak

• CHEM–C 583 Physiological Chemistry (3 cr.) P: P580. Includes the biochemical basis of genetic diseases of carbohydrate, lipid, and protein metabolism; the mechanisms of hormone actions; plasma components, particularly those of the clotting mechanism; the biochemistry of the red blood cell; and the biochemical basis for clinical nutrition. Daleke and Walczak

Pathology

• PATH–C 601 General Pathology (5 cr.) Principles of pathology, including a comprehensive introduction to mechanisms of reaction to injury and pathogenesis of disease processes. Braun and Staff

• PATH–C 602 Systemic Pathology (6 cr.) Review of human pathology by organ systems. Braun and Staff

Pharmacology

• PHAR–F 605 Principles of Pharmacology I (4 cr.) P: P531-P532 or consent of instructor. Basic principles and clinical aspects of modern pharmacology presented in lectures. Physicochemical properties of drugs. Drugs that affect the autonomic nervous system. Drugs that act on cardiovascular and renal systems. Chemotherapy of cancer, infections, and parasites. Watkins and Staff

• PATH–C 606 Principles of Pharmacology II (4 cr.) P: F605. Drugs that influence the central nervous system. Drugs that influence gastrointestinal and endocrine systems. Immunopharmacology and the pharmacology of allergy and inflammation. Toxicology. Watkins and Staff

Medicine

• MCSI–M 485 Physiology of Human Disease (4 cr.) This course will explore the scientific and social aspects of three common diseases: diabetes mellitus, cardiovascular disease, and breast cancer. Students will learn about these diseases through didactic lecture, observations of patients in clinics, doctors’ offices, or hospital settings. Carr

• MED–M 505 Human Genetics and Development (2 cr.) An introduction to the genetics of human traits and inheritable diseases; normal and abnormal development of the human from embryonic life through early childhood. Open only to students in the School of Medicine. Forrester

• MED–M 555 Medical Neurosciences (5 cr.) An interdisciplinary study of the morphological, functional, and clinical aspects of the human nervous system. Ronan, Suthers, and Staff

• MCSI–M 605 Introduction to Medicine I (10 cr.) A multidepartmental course designed to introduce clinical medicine. Includes medical history-taking and physical examination skills learned at the bedside with direct patient contact. Clinical medicine is surveyed concurrently with the emphasis on pathophysiology and diagnosis. Problem-solving skills are stressed, including synthesis and interpretation of medical data. Hrisomalos and Staff

• MCSI–M 606 Introduction to Medicine II (10 cr.) P: M605. Extension and application of techniques acquired in M605, including workups of patients, medical rounds, and clinicopathological conferences. Hrisomalos and Staff

• MCSI–X 600 Patient/Physician Relationship (2 cr.) A multidepartmental, interdisciplinary course designed to introduce students to the patient-doctor relationship through interactions with faculty and patients in a variety of settings. In small groups facilitated by primary care and behavioral science faculty, students direct their learning toward the complexity of the context from which a patient seeks medical care. To achieve this, students examine normal human behavior and development throughout the life cycle. Issues addressed include preventive health care, sexuality, cultural diversity, minority health issues, religion and spirituality, family dynamics, the economics of health care, and death and dying. Hrisomalos, Watkins, and Staff

• MCSI–X 603 Biostatistics (1 cr.) An introductory course in biostatistics for medical students. Mynark

Microbiology/Immunology

• MCSI–M 540 Microbiology/Immunology (5 cr.) Basic concepts of immunology, microorganisms as agents of disease, host-parasite relationships, epidemiology, chemotherapy. Hrisomalos

Physiology

• PHSL–P 531 Human Physiology I (3 cr.) Basic principles of general physiology; cardiovascular, digestion, respiration, and renal physiology relevant to humans. Martin and Staff

• PHSL–P 532 Human Physiology II (5 cr.) P: P531. Basic physiological principles of temperature regulation, metabolism, endocrinology, and neurophysiology relevant to humans. Martin and Staff

Courses for Undergraduate Students

Anatomy

• ANAT–A 215 Basic Human Anatomy (5 cr.) (Fall, Spring, Summer II) Intended for science majors and not recommended for first-semester freshmen. This course is team-taught by Medical Sciences faculty. An organ systems approach to the study of the human body, including microscopic and gross structure. The course starts with an introduction to basic cell structure and tissue construction, and continues with the coverage of all human systems with emphasis on the musculoskeletal system, cardiovascular, reproductive, and nervous systems. Bones, models, and prosected cadavers are used to study these topics concurrently in the laboratory. Three lecture periods and two two-hour laboratory and lecture exams are given outside the regularly scheduled class time. Please see the Schedule of Classes for exam times. There are required textbooks for both lecture and laboratory portions of this course, with additional materials provided on the Internet.

• ANAT–A 464 Human Tissue Biology (4 cr.) (Spring) This course will provide undergraduates with an in-depth understanding of the biology of human tissues and organs at the cellular and molecular level. Emphasis will be on the normal structural and functional relationships of adult tissues, but will include certain aspects of embryonic tissue formation and medically important tissue abnormalities. After discussing the molecular basis of fundamental types of tissues, we will consider each of the organ systems, including the nervous system, immune system, endocrine system, and reproductive systems. Developmental aspects of certain specialized tissues such as bone, teeth, and blood cells will be covered in greater detail.

Medical Sciences

• MCSI–M 131 Disease and the Human Body (3 cr.) (Fall, Spring) Suitable for non-science majors at all levels. Basic science knowledge is advantageous but not necessary. This course is team-taught by Medical Sciences faculty. Provided will be a description of a disease or injury and a discussion of the normal anatomy and physiology of relevant body systems and the alterations because of the disease or injury. Included will be various drug and other medical interventions that can be used to diagnose and treat the diseases and injuries. The format consists primarily of lectures with some interactive demonstrations. Four objective exams are scheduled throughout the semester and standard grading policies are utilized. No text is required, and extensive handouts are provided.

• MCSI–M 216 Medical Science of Psychoactive Drugs (3 cr.) (Fall, Spring) An entry-level examination of the biological mechanisms underlying the effects of psychoactive drugs. Drug actions in the brain, spinal cord, heart, lungs, liver, and other organs and tissues will be detailed. Molecular mechanisms and genetic factors involved in drug-induced therapeutic and adverse effects will be emphasized. No single appropriate textbook exists. Handouts generated from multiple sources will be provided to cover lecture material.

• MCSI–M 450 Undergraduate Research for Biomedical Science (1–6 cr.) P: Written permission of faculty member supervising the research and the undergraduate research advisor. Introduction to research methods and scientific investigation in the biomedical sciences. Written report is required upon completion of the research.

• MCSI–M 485 Physiology of Human Disease (4 cr.) Course will explore the scientific and social aspects of three common diseases: diabetes mellitus, cardiovascular disease, and breast cancer. Students will learn about these diseases through didactic lecture, observations of patients in clinics, doctors’ offices, or hospital settings. Carr

• MCSI–M 490 Special Topics in Biomedical Science (1–6 cr.) Intensive study of a selected topic in biomedical sciences. Topics will vary.

• MCSI–M 499 Internship in Medical Science Instruction (3 cr.) P: Anatomy A215 and/or Physiology P215 and consent of instructor. Supervised teaching experience in undergraduate medical science courses. May be repeated only once for credit. May be repeated only once for credit.

Physiology

• PHSL–P 130 Human Biology (4 cr.) Basic concepts in human biology. Covers reproduction and development, physiological regulations, stress biology, and behavioral biology; emphasizes related social problems.

• PHSL–P 215 Basic Human Physiology (5 cr.) (Fall, Spring, Summer II) Intended for science majors and not recommended for first-semester freshmen. It is recommended but not required that students complete A215 and C101 prior to enrollment in P215. This course is team-taught by Medical Sciences faculty. An organ systems approach to the study of human body function. Presentation begins with basic cell function and communication systems of the body, progressing to control systems, defense mechanisms, transport, gas exchange, and balancing of nutrients, water, and electrolytes. Focus for the course is on how organ systems contribute to essential metabolic activity and the maintenance of homeostasis. The laboratory emphasizes the application of material presented during lecture and is a required part of the course. Four lecture periods and one-hour laboratory session per week. Separate objective laboratory and lecture exams are given outside of the regular scheduled class time. Please see the Schedule of Classes for exam times. There are required textbooks for both lecture (same text as A215) and laboratory portions of this course with additional materials provided on the Internet.

• HPER–P 409 Physiology of Exercise (4 cr.) P: An introductory biology course and general chemistry. Lectures and laboratory on the regulation and integration of metabolic, cardiovascular, and respiratory functions in response to varying intensities of exercise. The influences of these stresses and responses on certain organs and systems, including liver, kidneys, skin, and the gastrointestinal tract.

• PHSL–P 416 Comparative Animal Physiology (3 cr.) P: Two college biology courses, a college mathematics course, Chemistry C106. Lectures on physiological principles of the respiratory, circulatory, excretory, and related systems in a variety of invertebrate and vertebrate animals.

• PHSL–P 417 Neurobiology (2 cr.) P: An introductory biology course and Chemistry C106. R: a course in cellular physiology or S308 or P416. Physiology of nerves and muscles including sensory receptors, peripheral and central processing of neural information, coordination of motor output, and neurophysiological correlates of behavior.

• PHSL–P 418 Laboratory in Comparative Animal Physiology (2 cr.) P: P416. C: P416. Laboratory experiments using a variety of animals to illustrate physiological principles.

• PHSL–P 421 Principles of Human Physiology (3–5 cr.) Intended for science majors. Permission of instructor required. This course offers an organ systems approach to the study of biophysical principals governing human body function. Lectures provide a broad survey of the communication and control systems of the body, defense mechanisms, transport, gas exchange, and balancing of nutrients, water, and electrolytes. Problem-solving skills, critical evaluation of data, research and resources in the study of physiology.

• PHSL–P 431 Human Physiology (4 cr.) (Fall, Spring) Intended for science majors. This is an introductory course in human physiology designed to introduce the senior undergraduate student and master’s-level graduate student to the function of the human body. This course provides a basic understanding of human organ system function. The emphasis is on demonstrating how organ systems work to maintain homeostasis, a constant yet dynamic internal state that enables us to deal with diverse environmental conditions and activities. Concepts are presented so as to provide students insight into the scientific process, problem solving, and knowledge of resources for the study of human body in health and disease. An opportunity to explore physiological concepts through discussion and experimentation is incorporated into the lecture format of this course. Assignments and exams include seven laboratory reports, seven discussion exercises, four semester exams, and one comprehensive final exam. There is a required textbook; additional materials are provided on the Internet.

• PHSL–P 432 Healing Outreach Program Elective (HOPE) (2 cr.) P: Consent of instructor. A service-learning course exploring the health and healing benefits of animals. This course partners companion animals, community volunteers, students, and facilities caring for the well-being of people who are physically and/or behaviorally compromised. Reflection and discussion will enhance basic knowledge of physiology and behavior and introduce related research.

Graduate Courses and Electives

The courses listed below are primarily intended for students seeking the M.S. or Ph.D. degree in the biomedical sciences and for medical students seeking a combined M.D. and graduate degree. Complete program information is provided in the Indiana University Graduate School Bulletin and/or departmental or program brochures.

Anatomy

• ANAT–A 464 Histology (5 cr.)

• ANAT–A 505 Human Development (1 cr.) P: Consent of instructor. Normal and abnormal human development, with a general consideration of human embryology from fertilization through the early neonatal period followed by more detailed analysis of topics in mammalian development biology and teratology.

• ANAT–A 512 Introduction to Research in Anatomy (1 cr.) Required of all new graduate students. Lectures and demonstrations in current research interests of faculty.

• ANAT–A 513 Introduction to Research Techniques (1 cr.) P: A512. Individual work on a research problem. Staff

• ANAT–A 530 Special Topics (2 cr.)

• ANAT–A 550 Gross Human Anatomy I (4 cr.)

• ANAT–A 551 Gross Human Anatomy II (4 cr.)

• MED–M 555 Medical Neuroscience (5 cr.) An interdisciplinary study of the morphological, functional, and clinical aspects of the human nervous system.

• ANAT–A 560 Human Microscopic Anatomy (4 cr.)

• ANAT–A 601 Advanced Gross Anatomy I (4 cr.) P: A551, consent of instructor. Structure of the upper and lower extremities.

• ANAT–A 602 Advanced Gross Anatomy II (4 cr.) P: A551, consent of instructor. Thorax, abdomen, and pelvis.

• ANAT–A 603 Advanced Gross Anatomy III (4 cr.) P: A551, consent of instructor. Head, neck, and gross brain. All include detailed dissection and lectures and discussion on current literature to determine relation of structure to function.

• ANAT–A 610 Comparative Neuroanatomy (2 cr.) P: Consent of instructor, graduate standing, and one neuroscience course or equivalent. A comparison of the central nervous system of mammalian and nonmammalian vertebrates, including a laboratory study of representative specimen.

• ANAT–A 664 Selected Topics in Advanced Microscopic Anatomy (2 cr.) P: A560 or consent of instructor. Advanced instruction in the microscopic structure of selected animal cell systems, involving discussion and review of current literature and research with these systems. Topic will change with each offering.

• ANAT–A 800 Research in Anatomy (arr. cr.)

• ANAT–A 850 Seminar in Anatomy and Physiology Medicine (arr. cr.)

• MSCI–G 901 Advanced Research (6 cr.) Authorized by director.

Pathology

• PATH–C 601 General Pathology (5 cr.)

• PATH–C 602 Systemic Pathology (6 cr.)

• PATH–C 800 Advanced Pathology (arr. cr.) P: C603. Subject material and hours arranged to conform to needs of students.

• PATH–C 858 Experimental Pathology (5 cr.) Review and performance of selected experiments in pathology illustrating the types of pathologic processes.

• PATH–C 859 Research in Pathology (arr. cr.) Supervised initiation of a research project in pathology. Counseling in the completion of a thesis.

• PATH–C 862 Basic Pathologic Techniques (5 cr.) Methods of the histologic and chemical laboratories of pathology; principles of examination used in the usual procedures of surgical and autopsy pathology.

• PATH–C 875 Biochemical Pathology (3 cr.) P: C603 or B800. A survey of biochemical pathology as demonstrated by recent advances in research in pathology. Selected topics for lecture and discussion will include aspects of tissue, cellular, subcellular, and molecular pathology.

Pharmacology

• PHAR–F 605 Principles of Pharmacology I (4 cr.)

• PHAR–F 606 Principles of Pharmacology II (4 cr.)

• PHAR–F 611 Methods of Pharmacology I (3 cr.) P: Consent of instructor. Chemical and biological procedures used in pharmacological research. Lectures and demonstrations of techniques used for the determination of specific substances in biological material.

• PHAR–F 612 Methods of Pharmacology II (3 cr.) P: F611. Laboratory application of principles and techniques presented in F611 to practical problems in pharmacological research. Introduction to data handling.

• PHAR–F 613 Graduate Pharmacology I (3 cr.) P: F605-F606 or consent of instructor. Molecular mechanisms of drug action, drug-receptor interactions, drug metabolism, and pharmacokinetics.

• PHAR–F 614 Graduate Pharmacology II (3 cr.) P: F513 or consent of instructor. Continuation of F513. Molecular mechanisms of drug action, drug-receptor interactions, drug metabolism and pharmacokinetics.

• PHAR–F 615 Chemotherapeutic Pharmacology (3 cr.) P: F605-F606 or consent of instructor. Basic principals of use of drugs as selectively toxic agents and of chemotherapy of bacterial, parasitic or viral diseases and malignancies.

• PHAR–F 616 Molecular Pharmacology (3 cr.) P: F605-F606 or consent of instructor. Molecular mechanisms as they relate to drug action. Biological transducers, receptor mechanisms, subcellular phenomena in the actions of drugs on mammalian systems.

• PHAR–F 617 Pharmacology of Drug Metabolism (3 cr.) P: F605-F606 or consent of instructor. Physicochemical principles involved in the absorption, distribution, metabolism, and excretion of drugs and other foreign compounds in the mammalian organism.

• PHAR–F 618 Pharmacokinetics (3 cr.) P: F617. Kinetic aspects of absorption, distribution, and excretion of drugs in the mammalian organism. Compartmentalization, multiphasic decay curves, and computerized treatments.

• PHAR–F 619 Endocrine Pharmacology (3 cr.) P: F605-F606 or consent of instructor. The pharmacology of hormones. Biosynthesis, structures, actions, and degradation of hormones endogenous to mammalian species. Structure and pharmacological activity of synthetic analogs and antagonists of naturally occurring hormones.

• PHAR–F 620 Special Topics in Pharmacology (3 cr.) P: F605-F606 or consent of instructor. Special topics of current interest in pharmacology. May be repeated. May be repeated.

• PHAR–F 621 Readings in Pharmacology (1–3 cr.) Supplementary readings and tutorial discussions in aspects of pharmacology to fit the needs of individual students or for specialized areas.

• PHAR–F 625 Research in Pharmacology (arr. cr.) Original research as approved by the department.

• PHAR–F 630 Seminar in Pharmacology (1 cr.) Research reports by students, faculty, and invited guests.

Physiology

• HPER–P 409 Physiology of Exercise (4 cr.)

• PHSL–P 416 Comparative Animal Physiology (3 cr.)

• PHSL–P 417 Neurobiology (3 cr.)

• PHSL–P 418 Laboratory in Comparative Animal Physiology (2 cr.)

• PHSL–P 421 Principles of Human Physiology (3–5 cr.) Intended for science majors. Permission of instructor required. This course offers an organ systems approach to the study of biophysical principles governing human body function. Lectures provide a broad survey of the communication and control systems of the body, defense mechanisms, transport, gas exchange, and balancing of nutrients, water, and electrolytes. Problem-solving skills, critical evaluation of data, research, and resources in the study of physiology.

• PHSL–P 509 Physiological Adaptations (3 cr.) Mechanisms of adaptation and acclimatization of invertebrate and vertebrate animals to environmental conditions. Seminar-type course.

• PHSL–P 510 Control Systems Theory in Biology (4 cr.) P: Introduction to calculus; P531 or equivalent. Predicting the properties of physiological systems from the dynamic properties of their component parts. Laboratory emphasizes analog and digital simulation techniques.

• PHSL–P 512 Introduction to Research in Physiology (1 cr.) Required of all new graduate students. Introduction to areas and methods of current faculty research.

• PHSL–P 513 Introduction to Research Techniques (1 cr.) P: P512. Individual work on a research problem.

• PHSL–P 530 Special Topics (arr. cr.) P: Consent of instructor. Work in advanced areas in physiology.

• PHSL–P 531 Human Physiology I (3 cr.)

• PHSL–P 532 Human Physiology II (5 cr.)

• PHSL–P 541 Advanced Physiology I: Neurophysiology (3–5 cr.) P: P531 or consent of instructor. From molecular to behavioral level, with special emphasis on electrophysiology and reflexes.

• PHSL–P 543 Neurophysiology Seminar (2 cr.) P: P541. May be taken more than once with consent of the department, for a maximum of 6 credit hours. May be taken more than once with consent of the department, for a maximum of 6 credit hours.

• PHSL–P 547 Topical Seminar in Physiology (2 cr.) P: Graduate standing and consent of instructor. Discussion and review of current research and literature in physiology. Topic and instructor will change from semester to semester.

• MED–P 548 Neuroethology (2 cr.) P: Consent of instructor. The function of nerve cells in controlling the natural behavior of animals. Sensory, integrative, and motor processes underlying selected behavior patterns of invertebrate and vertebrate animals.

• PHSL–P 550 Seminar in Physiology (1–5 cr.) Discussion and review of current research and literature in selected topics, including neural, temperature regulation, cardiovascular, renal, and respiratory physiology.

• PHSL–P 551 Advanced Physiology II: Circulation, Respiration (3 cr.) P: P531 or equivalent. Lecture and seminar discussions of current literature with emphasis on physical models.

• PHSL–P 561 Advanced Comparative Animal Physiology (3 cr.) P: P531, P416 or equivalent, or consent of instructor. Lectures and discussions of current literature on mechanisims and adaptations of respiration, temperature regulation, locomotion, and osmoregulation from a comparative approach. Topics will be covered in succeeding years on a rotating basis. May be taken more than once for different topics. May be taken more than once for different topics.

• PHSL–P 575 Advanced Physiology: Exercise (3 cr.) P: P532 or consent of instructor. Study of the regulation and integration of metabolic, cardio-vascular, respiratory, endocrinological, and biochemical functions of the human body in response to exercise of all types and durations.

• PHSL–P 576 Advanced Physiology: Work and Environmental (3 cr.) P: P575 or consent of instructor. Mechanisms of contraction and neuromuscular control. Metabolic energy, cost efficiency, and the fuels of work. The adjustments and regulation of chemical and thermal homeostasis. Effects of environmental factors, training, age, health, and disease on metabolic, cardiovascular, and respiratory adjustments to exercise.

• PHSL–P 620 Renal Physiology (3 cr.) P: P531, A464, P551, C580. Designed for graduate students in physiology. Covers recent advances in acid-base balance, blood pressure regulations, and salt balance in relation to endocrinology.

• PHSL–P 800 Research in Physiology (arr. cr.)

• PHSL–L 500 Independent Study (arr. cr.) P: Written permission of faculty member supervising research.