School of Medicine
(An asterisk [*] denotes associate membership in University Graduate School faculty.)
(See also general University Graduate School requirements.)
Ph.D. Minor in Cellular and Molecular Biology of Biomedical Systems
Ph.D. Minor in Cancer Biology
J510 Infectious Microbes and Host Interactions (3 cr.) P: graduate-level biochemistry. Emphasis on the molecular and cellular events which permit pathogenic bacteria and viruses to enter human cells and disrupt cell function while evading the host's immune system.
J601 Medical Immunology (2 cr.) Introduction to natural and acquired immune mechanisms, with consideration of their significance to medicine. Topics will include both normal and abnormal immune processes, including recovery from and prevention of disease, immune-mediated pathological processes, tumor immunology, immunodeficiency, and auto-immunity. Designed to precede and complement J602 Medical Microbiology.
J800 Advanced Microbiology (cr. arr.)** P: consent of instructor. The approach to problems in microbiology, including the application of techniques of bacteriology, genetics, immunology, mycology, parasitology, virology, and zoology.
J802 Introduction to Research (2 cr.) P: consent of instructor. Laboratory research instruction in microbiology and immunology. Purpose is to introduce students to three different research programs in microbiology and/or immunology.
J805 Molecular Immunology (3 cr.) P: B500 or equivalent; consent of instructor. Characterization of immunologically relevant molecules in terms of molecular genetics, synthesis and assembly, structure-function and evolutionary relationships, and functional roles in immune responses. Entities to be considered include members of the immunoglobulin superfamily and functionally associated molecules.
J806 Immunochemistry: Laboratory (cr. arr.) P: J805 C. Antigen preparation; separation and purification of antibodies; modern methods of antibody determination and analysis.
J807 Current Topics in Immunology (2 cr.) PP: graduate standing, J805 or J840 or equivalent or consent of instructor. Discussion and review of current literature in selected topics in immunology. Emphasis on molecular and cellular events in lymphocyte activation and regulation. Topic varies from year to year. May be repeated for credit.
J810 Research in Microbiology (cr. arr.)** P: consent of instructor. Data obtained in this course may be used to meet the thesis requirements for graduate degrees.
J821 Microbial Pathogenicity (3 cr.) P: consent of instructor. This course will consider in detail the determinants of microbial virulence and the mechanisms of host responses to infection and how these two factors interact in the pathogenesis of infectious diseases.
J822 General and Medical Microbiology (3 cr.) Lectures covering the biology of various pathogenic organisms such as bacteria, viruses, fungi, and parasites, their role in human disease with emphasis on determinants of microbial virulence, the mechanisms of host responses to infection, and the role of these factors in the pathogenesis of disease.
J826 Bacteriology (3 cr.) P: J601 or J822 or their equivalent and consent of instructor. General concepts of bacteriology.
J828 Virology: Lecture (3 cr.) P: BIOC B500 or equivalent and consent of instructor. Basic biological principles of viruses; agents causing diseases in animals, including humans; interactions of animal viruses with their host cells in tissue culture.
J829 Current Topics in Molecular Genetics of Microorganisms (2 cr.) P: graduate standing, J821, J828 or G865, consent of instructor. In-depth study of a specific topic in contemporary molecular genetics of microorganisms. Topic varies; may be taken for credit more than once.
J830 Seminar in Microbiology (1 cr.) P: consent of instructor. Provides students with background and practical experience in communication of their research.
J840 Mechanisms of Immune Regulation (2 cr.) P. consent of instructor. A current overview of the cellular mechanisms which regulate immune responses. Topics include cells and cytokines involved in antigen presentation, lympocyte activation and function, development, and tolerance.
J842 Neoplastic Determinants (2 cr.) G865, G817 or equivalent and consent of instructor. Focus on the genetic basis of the cancer phenotype. Consider effects of DNA sequence mutations; chromosomal rearrangements, and/or introduction of new genetic information on DNA repair, oncogene products and tumor suppressors. Intra- and intercellular consequences of these discrete alteractions will be included.
J854 Hematopoiesis (2 cr.) P: G817, G865, and consent of the instructor. Principles of blood cell formation, including the regulation of production, biologic function, and cell culture and recombinant DNA technologies that contribute to our understanding. Stem cells, growth factors, cytokine involvement, gene transfer/gene therapy, and clinical applications.
GRAD G504 Introduction to Research Ethics (2 cr.) Introduction to the basic concepts of research ethics. The course will cover historical development of concern with ethics in science as well as practical information needed by students working in the science today. Format will be lecture and discussion.
GRAD G817 Eukaroytic Cell Biology (2 cr.) P: one semester of biochemistry. Organization and function of subcellular structures. Intracellular coordination of cell activity: protein and RNA trafficking, chromatin dynamics, and intracellular processing of receptor mediated signals.
GRAD G837 Mammalian DNA Repair and Disease (3 cr.) P: consent of instructor. The molecular biology of genetic repair and mutation; emphasis on human systems and human disease states related to DNA repair; mechanisms of DNA repair and regulation of DNA repair in mammalian cells.
GRAD G865 Fundamental Molecular Biology (3 cr.) P: B800 or equivalent. Principles of molecular structure, function, and biosynthesis; core information regarding prokaryotic and eukaryotic gene continuity and metabolic coordination; introduction to multicellular systems and problems.
**These courses are eligible for a deferred grade.